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    CTL1 polynucleotide 5'-phosphatase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855218, updated on 29-Jun-2024

    Summary

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    Gene symbol
    CTL1
    Gene description
    polynucleotide 5'-phosphatase
    Primary source
    FungiDB:YMR180C
    Locus tag
    YMR180C
    See related
    SGD:S000004792; AllianceGenome:SGD:S000004792; VEuPathDB:YMR180C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CTH1
    Summary
    Enables polynucleotide 5'-phosphatase activity. Predicted to be involved in 7-methylguanosine mRNA capping and polynucleotide 5' dephosphorylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CTL1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (622251..623213, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Fpy1p Neighboring gene Spt21p Neighboring gene uncharacterized protein Neighboring gene Rgm1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Saccharomyces cerevisiae RNA 5'-triphosphatase related to mRNA capping enzyme. Rodriguez CR, et al. Nucleic Acids Res, 1999 May 15. PMID 10219091, Free PMC Article
    2. Mutational analyses of yeast RNA triphosphatases highlight a common mechanism of metal-dependent NTP hydrolysis and a means of targeting enzymes to pre-mRNAs in vivo by fusion to the guanylyltransferase component of the capping apparatus. Pei Y, et al. J Biol Chem, 1999 Oct 8. PMID 10506129
    3. Genome-wide screen identifies host genes affecting viral RNA recombination. Serviene E, et al. Proc Natl Acad Sci U S A, 2005 Jul 26. PMID 16027361, Free PMC Article
    4. Identification of novel Saccharomyces cerevisiae proteins with nuclear export activity: cell cycle-regulated transcription factor ace2p shows cell cycle-independent nucleocytoplasmic shuttling. Jensen TH, et al. Mol Cell Biol, 2000 Nov. PMID 11027275, Free PMC Article
    5. Functional organization of the S. cerevisiae phosphorylation network. Fiedler D, et al. Cell, 2009 Mar 6. PMID 19269370, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 5'-triphosphate monophosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polynucleotide 5'-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polynucleotide 5'-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables polynucleotide 5'-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 7-methylguanosine mRNA capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mRNA capping enzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    polynucleotide 5'-phosphatase
    NP_013905.1
    • RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm; CTL1 has a paralog, CET1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      622251..623213 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182686.1 → NP_013905.1  TPA: polynucleotide 5'-phosphatase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013905.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W003, Q03220
      UniProtKB/TrEMBL
      A0A8H4BXJ4, A6ZMP0, B3LM66, C8ZF43, N1P5R1
      Conserved Domains (1) summary
      pfam02940
      Location:61 → 278
      mRNA_triPase; mRNA capping enzyme, beta chain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03220.1

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