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    PEP5 tethering complex subunit PEP5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855271, updated on 28-Oct-2024

    Summary

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    Official Symbol
    PEP5
    Official Full Name
    tethering complex subunit PEP5
    Primary source
    SGD:S000004844
    Locus tag
    YMR231W
    See related
    AllianceGenome:SGD:S000004844; FungiDB:YMR231W; VEuPathDB:YMR231W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    END1; VAM1; VPL9; VPS11; VPT11
    Summary
    Enables ubiquitin protein ligase activity. Contributes to phosphatidylinositol binding activity. Involved in several processes, including Golgi to endosome transport; histone catabolic process; and vacuole fusion, non-autophagic. Located in fungal-type vacuole membrane. Part of CORVET complex and HOPS complex. Used to study Parkinson's disease and hypomyelinating leukodystrophy 12. Human ortholog(s) of this gene implicated in dystonia 32 and hypomyelinating leukodystrophy 12. Orthologous to human VPS11 (VPS11 core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See PEP5 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (733545..736634)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S10B Neighboring gene uncharacterized protein Neighboring gene Fus2p Neighboring gene Tri1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of PEP5, a gene essential for vacuolar biogenesis in Saccharomyces cerevisiae. Woolford CA, et al. Genetics, 1990 Aug. PMID 2204580, Free PMC Article
    2. Characterization of the END1 gene required for vacuole biogenesis and gluconeogenic growth of budding yeast. Dulić V, et al. EMBO J, 1989 May. PMID 2670552, Free PMC Article
    3. Role of protein processing, intracellular trafficking and endocytosis in production of and immunity to yeast killer toxin. Douglas CM, et al. Eur J Epidemiol, 1988 Dec. PMID 3060366
    4. A putative zinc finger protein, Saccharomyces cerevisiae Vps18p, affects late Golgi functions required for vacuolar protein sorting and efficient alpha-factor prohormone maturation. Robinson JS, et al. Mol Cell Biol, 1991 Dec. PMID 1840635, Free PMC Article
    5. Hypomyelination and developmental delay associated with VPS11 mutation in Ashkenazi-Jewish patients. Edvardson S, et al. J Med Genet, 2015 Nov. PMID 26307567

    See all (124) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to endosome transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in histone catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in late endosome to vacuole transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in organelle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of SNARE complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vacuole fusion, non-autophagic IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vacuole fusion, non-autophagic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuole organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle docking involved in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle tethering IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CORVET complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of HOPS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of HOPS complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in bounding membrane of organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vesicle tethering complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tethering complex subunit PEP5
    NP_013958.1
    • Histone E3 ligase, component of CORVET membrane tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p; involved in ubiquitination and degradation of excess histones

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      733545..736634
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182738.1 → NP_013958.1  TPA: tethering complex subunit PEP5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013958.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W057, P12868
      UniProtKB/TrEMBL
      B3LMC0, B5VPZ9, N1NZ20
      Conserved Domains (3) summary
      cd00162
      Location:928 → 972
      RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
      pfam12451
      Location:976 → 1021
      VPS11_C; Vacuolar protein sorting protein 11 C terminal
      cl17238
      Location:928 → 975
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12868.2

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