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    PEP5 tethering complex subunit PEP5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855271, updated on 28-Oct-2024

    Summary

    Official Symbol
    PEP5
    Official Full Name
    tethering complex subunit PEP5
    Primary source
    SGD:S000004844
    Locus tag
    YMR231W
    See related
    AllianceGenome:SGD:S000004844; FungiDB:YMR231W; VEuPathDB:YMR231W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    END1; VAM1; VPL9; VPS11; VPT11
    Summary
    Enables ubiquitin protein ligase activity. Contributes to phosphatidylinositol binding activity. Involved in several processes, including Golgi to endosome transport; histone catabolic process; and vacuole fusion, non-autophagic. Located in fungal-type vacuole membrane. Part of CORVET complex and HOPS complex. Used to study Parkinson's disease and hypomyelinating leukodystrophy 12. Human ortholog(s) of this gene implicated in dystonia 32 and hypomyelinating leukodystrophy 12. Orthologous to human VPS11 (VPS11 core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

    See PEP5 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (733545..736634)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S10B Neighboring gene uncharacterized protein Neighboring gene Fus2p Neighboring gene Tri1p

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to endosome transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in endosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in histone catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in late endosome to vacuole transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in organelle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of SNARE complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vacuole fusion, non-autophagic IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vacuole fusion, non-autophagic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vacuole organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle docking involved in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle tethering IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of CORVET complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of HOPS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of HOPS complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in bounding membrane of organelle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
     
    part_of vesicle tethering complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tethering complex subunit PEP5
    NP_013958.1
    • Histone E3 ligase, component of CORVET membrane tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p; involved in ubiquitination and degradation of excess histones

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      733545..736634
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182738.1NP_013958.1  TPA: tethering complex subunit PEP5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013958.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W057, P12868
      UniProtKB/TrEMBL
      B3LMC0, B5VPZ9, N1NZ20
      Conserved Domains (3) summary
      cd00162
      Location:928972
      RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
      pfam12451
      Location:9761021
      VPS11_C; Vacuolar protein sorting protein 11 C terminal
      cl17238
      Location:928975
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain