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    AQR1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855660, updated on 22-Aug-2024

    Summary

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    Official Symbol
    AQR1
    Primary source
    FungiDB:YNL065W
    Locus tag
    YNL065W
    See related
    SGD:S000005009; AllianceGenome:SGD:S000005009; VEuPathDB:YNL065W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables monocarboxylic acid transmembrane transporter activity and xenobiotic transmembrane transporter activity. Involved in amino acid export across plasma membrane and monocarboxylic acid transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See AQR1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (503724..505484)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L9B Neighboring gene putative glucosidase SUN4 Neighboring gene type I HSP40 co-chaperone YDJ1 Neighboring gene S-adenosylmethionine-dependent methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AQR1 gene (ORF YNL065w) encodes a plasma membrane transporter of the major facilitator superfamily that confers resistance to short-chain monocarboxylic acids and quinidine in Saccharomyces cerevisiae. Tenreiro S, et al. Biochem Biophys Res Commun, 2002 Apr 5. PMID 11922628
    2. Saccharomyces cerevisiae Aqr1 is an internal-membrane transporter involved in excretion of amino acids. Velasco I, et al. Eukaryot Cell, 2004 Dec. PMID 15590823, Free PMC Article
    3. Combined roles of exporters in acetic acid tolerance in Saccharomyces cerevisiae. Zhang X, et al. Biotechnol Biofuels Bioprod, 2022 Jun 18. PMID 35717394, Free PMC Article
    4. Overlapping Roles of Yeast Transporters Aqr1, Qdr2, and Qdr3 in Amino Acid Excretion and Cross-Feeding of Lactic Acid Bacteria. Kapetanakis GC, et al. Front Microbiol, 2021. PMID 34887841, Free PMC Article
    5. The intralumenal fragment pathway mediates ESCRT-independent surface transporter down-regulation. McNally EK, et al. Nat Commun, 2018 Dec 18. PMID 30560896, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aqr1 catalyzes transport of excess amino acids into vesicles, which then release them in the extracellular space by exocytosis
      Title: Saccharomyces cerevisiae Aqr1 is an internal-membrane transporter involved in excretion of amino acids.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables monocarboxylic acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables threonine efflux transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables xenobiotic transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid export across plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in amino acid export across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monocarboxylic acid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in threonine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in xenobiotic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in cytoplasm HDA PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Aqr1p
    NP_014334.3
    • Plasma membrane transporter of the major facilitator superfamily; involved in the excretion of excess amino acids; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; relocalizes from plasma membrane to cytoplasm upon DNA replication stress; AQR1 has a paralog, QDR1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      503724..505484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182903.3 → NP_014334.3  TPA: Aqr1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014334.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1B5, P53943, Q6B1F8
      UniProtKB/TrEMBL
      A6ZS15, N1NZH9
      Conserved Domains (1) summary
      cd17323
      Location:103 → 553
      MFS_Tpo1_MDR_like; Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53943.1

    Gene LinkOut

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