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    SPS18 Sps18p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855517, updated on 1-Aug-2024

    Summary

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    Gene symbol
    SPS18
    Gene description
    Sps18p
    Primary source
    FungiDB:YNL204C
    Locus tag
    YNL204C
    See related
    SGD:S000005148; AllianceGenome:SGD:S000005148; VEuPathDB:YNL204C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SPX18
    Summary
    Predicted to enable GTPase activator activity. Involved in ascospore formation. Predicted to be active in Golgi membrane. Orthologous to human ARFGAP1 (ADP ribosylation factor GTPase activating protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SPS18 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (258375..259277, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene protein kinase RIO2 Neighboring gene Rtt106p Neighboring gene 2,4-dienoyl-CoA reductase (NADPH) Neighboring gene Psy2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mapping of the divergently transcribed sporulation-specific genes SPS18 and SPS19 to the left arm of chromosome XIV of Saccharomyces cerevisiae. Coe JG, et al. Yeast, 1994 Jun. PMID 7975900
    2. The Saccharomyces cerevisiae peroxisomal 2,4-dienoyl-CoA reductase is encoded by the oleate-inducible gene SPS19. Gurvitz A, et al. J Biol Chem, 1997 Aug 29. PMID 9268358
    3. Identification of a sporulation-specific promoter regulating divergent transcription of two novel sporulation genes in Saccharomyces cerevisiae. Coe JG, et al. Mol Gen Genet, 1994 Sep 28. PMID 7969036
    4. A 21.7 kb DNA segment on the left arm of yeast chromosome XIV carries WHI3, GCR2, SPX18, SPX19, an homologue to the heat shock gene SSB1 and 8 new open reading frames of unknown function. Jonniaux JL, et al. Yeast, 1994 Dec. PMID 7725799
    5. Regulation of the yeast SPS19 gene encoding peroxisomal 2,4-dienoyl-CoA reductase by the transcription factors Pip2p and Oaf1p: beta-oxidation is dispensable for Saccharomyces cerevisiae sporulation in acetate medium. Gurvitz A, et al. Mol Microbiol, 1997 Nov. PMID 9427398

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ascospore formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of ARF protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Sps18p
    NP_014195.1
    • hypothetical protein, contains a putative zinc-binding domain; expressed during sporulation; SPS18 has a paralog, GCS1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      258375..259277 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183042.1 → NP_014195.1  TPA: Sps18p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014195.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0Y5, P32572
      UniProtKB/TrEMBL
      G2WLQ8, N1NZ72
      Conserved Domains (1) summary
      COG5347
      Location:6 → 300
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32572.2

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