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    CUS2 U2 snRNP complex subunit CUS2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855430, updated on 17-May-2024

    Summary

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    Gene symbol
    CUS2
    Gene description
    U2 snRNP complex subunit CUS2
    Primary source
    FungiDB:YNL286W
    Locus tag
    YNL286W
    See related
    SGD:S000005230; AllianceGenome:SGD:S000005230; VEuPathDB:YNL286W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables U2 snRNA binding activity. Involved in RNA folding and U2-type prespliceosome assembly. Part of U2 snRNP. Orthologous to human HTATSF1 (HIV-1 Tat specific factor 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CUS2 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (95223..96080)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene CCR4-NOT core subunit CAF40 Neighboring gene coatomer subunit gamma Neighboring gene gag-pol fusion protein Neighboring gene tRNA-Gly Neighboring gene gag protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ATP requirement for Prp5p function is determined by Cus2p and the structure of U2 small nuclear RNA. Perriman R, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610285, Free PMC Article
    2. Conformational dynamics of stem II of the U2 snRNA. Rodgers ML, et al. RNA, 2016 Feb. PMID 26631165, Free PMC Article
    3. A splicing-dependent transcriptional checkpoint associated with prespliceosome formation. Chathoth KT, et al. Mol Cell, 2014 Mar 6. PMID 24560925, Free PMC Article
    4. Competition between the ATPase Prp5 and branch region-U2 snRNA pairing modulates the fidelity of spliceosome assembly. Xu YZ, et al. Mol Cell, 2007 Dec 14. PMID 18082608, Free PMC Article
    5. Prp5-Spt8/Spt3 interaction mediates a reciprocal coupling between splicing and transcription. Shao W, et al. Nucleic Acids Res, 2020 Jun 19. PMID 32399566, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables U2 snRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables U2 snRNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in RNA folding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in U2-type prespliceosome assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in U2-type prespliceosome assembly IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2 snRNP IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of U2-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    U2 snRNP complex subunit CUS2
    NP_014113.1
    • Putative checkpoint factor in transcription; binds to U2 snRNA and Prp11p; regulates toggling of the U2 snRNA stem II region between different structures; contains two RNA recognition motifs (RRMs)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      95223..96080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183124.1 → NP_014113.1  TPA: U2 snRNP complex subunit CUS2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014113.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0Q7, E9P8U4, P53830
      UniProtKB/TrEMBL
      A0A6A5Q4S6, A6ZSJ2, G2WLI1, N1NXX1
      Conserved Domains (2) summary
      cd12281
      Location:44 → 134
      RRM1_TatSF1_like; RNA recognition motif 1 (RRM1) found in HIV Tat-specific factor 1 (Tat-SF1) and similar proteins
      cd12285
      Location:182 → 262
      RRM3_RBM39_like; RNA recognition motif 3 (RRM3) found in vertebrate RNA-binding protein 39 (RBM39) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53830.1

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