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    NOP12 Nop12p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854116, updated on 29-Jun-2024

    Summary

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    Gene symbol
    NOP12
    Gene description
    Nop12p
    Primary source
    FungiDB:YOL041C
    Locus tag
    YOL041C
    See related
    SGD:S000005401; AllianceGenome:SGD:S000005401; VEuPathDB:YOL041C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables rRNA binding activity. Involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of preribosome. Orthologous to human RBM34 (RNA binding motif protein 34). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See NOP12 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (251267..252646, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene bifunctional N-glycosylase/AP lyase NTG2 Neighboring gene RNA exonuclease Neighboring gene ribosomal 40S subunit protein S15 Neighboring gene ribosomal protein P2A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleolar protein Nop12p participates in synthesis of 25S rRNA in Saccharomyces cerevisiae. Wu K, et al. Nucleic Acids Res, 2001 Jul 15. PMID 11452019, Free PMC Article
    2. Constitutively-stressed yeast strains are high-yielding for recombinant Fps1: implications for the translational regulation of an aquaporin. Cartwright SP, et al. Microb Cell Fact, 2017 Mar 9. PMID 28279185, Free PMC Article
    3. SUMO mediates interaction of Ebp2p, the yeast homolog of Epstein-Barr virus nuclear antigen 1-binding protein 2, with a RING finger protein Ris1p. Shirai C, et al. Biosci Biotechnol Biochem, 2008 Jul. PMID 18603780
    4. Roles of Ebp2 and ribosomal protein L36 in ribosome biogenesis in Saccharomyces cerevisiae. Wan K, et al. Curr Genet, 2015 Feb. PMID 25119672
    5. Yeast Rrp14p is a nucleolar protein involved in both ribosome biogenesis and cell polarity. Yamada H, et al. RNA, 2007 Nov. PMID 17804645, Free PMC Article

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Misfolded pre-rRNAs are stable in the absence of Nop12 but rapidly turned over when Pwp1 is not present.
      Title: Ribosome assembly factors Pwp1 and Nop12 are important for folding of 5.8S rRNA during ribosome biogenesis in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Nop12p
    NP_014601.1
    • Nucleolar protein involved in pre-25S rRNA processing; also involved in biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      251267..252646 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183295.1 → NP_014601.1  TPA: Nop12p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014601.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W225, Q08208
      UniProtKB/TrEMBL
      A0A6L1A1Q7, B5VRL2, C7GK10, C8ZHS3, G2WMJ2, N1NY34
      Conserved Domains (2) summary
      cd12669
      Location:148 → 272
      RRM1_Nop12p_like; RNA recognition motif 1 (RRM1) found in yeast nucleolar protein 12 (Nop12p) and similar proteins
      cd12670
      Location:280 → 370
      RRM2_Nop12p_like; RNA recognition motif 2 (RRM2) found in yeast nucleolar protein 12 (Nop12p) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08208.1

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