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    MCH4 Mch4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854030, updated on 28-Oct-2024

    Summary

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    Official Symbol
    MCH4
    Official Full Name
    Mch4p
    Primary source
    SGD:S000005479
    Locus tag
    YOL119C
    See related
    AllianceGenome:SGD:S000005479; FungiDB:YOL119C; VEuPathDB:YOL119C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in riboflavin transport. Located in fungal-type vacuole membrane. Human ortholog(s) of this gene implicated in Allan-Herndon-Dudley syndrome; cataract 47; and intellectual disability. Orthologous to several human genes including SLC16A10 (solute carrier family 16 member 10) and SLC16A9 (solute carrier family 16 member 9). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See MCH4 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (94856..96361, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S19A Neighboring gene ribosomal 60S subunit protein L18A Neighboring gene uncharacterized protein Neighboring gene Rri2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption and basic functional analysis of six novel ORFs of chromosome XV from Saccharomyces cerevisiae. Lafuente MJ, et al. Yeast, 1999 Jul. PMID 10407273
    2. The putative monocarboxylate permeases of the yeast Saccharomyces cerevisiae do not transport monocarboxylic acids across the plasma membrane. Makuc J, et al. Yeast, 2001 Sep 15. PMID 11536335
    3. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Halestrap AP, et al. Biochem J, 1999 Oct 15. PMID 10510291, Free PMC Article
    4. The proline-dependent transcription factor Put3 regulates the expression of the riboflavin transporter MCH5 in Saccharomyces cerevisiae. Spitzner A, et al. Genetics, 2008 Dec. PMID 18940788, Free PMC Article
    5. A CRISPR/Cas9-based exploration into the elusive mechanism for lactate export in Saccharomyces cerevisiae. Mans R, et al. FEMS Yeast Res, 2017 Dec 1. PMID 29145596

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in riboflavin transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Mch4p
    NP_014522.1
    • Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      94856..96361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183373.1 → NP_014522.1  TPA: Mch4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014522.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1U9, Q08268
      UniProtKB/TrEMBL
      A6ZN92, B3LIU7, C7GSR8, G2WMB8, N1NW76
      Conserved Domains (1) summary
      cd17352
      Location:96 → 490
      MFS_MCT_SLC16; Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08268.1

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