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    ARG8 acetylornithine transaminase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854025, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ARG8
    Official Full Name
    acetylornithine transaminase
    Primary source
    SGD:S000005500
    Locus tag
    YOL140W
    See related
    AllianceGenome:SGD:S000005500; FungiDB:YOL140W; VEuPathDB:YOL140W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity. Predicted to be involved in L-arginine biosynthetic process and ornithine biosynthetic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ARG8 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (58759..60030)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene exosome non-catalytic core subunit RRP40 Neighboring gene tRNA methyltransferase PPM2 Neighboring gene translation initiation factor eIF4E Neighboring gene Rtc1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Further definition of the sequence and position requirements of the arginine control element that mediates repression and induction by arginine in Saccharomyces cerevisiae. Crabeel M, et al. Yeast, 1995 Nov. PMID 8585320
    2. Expression of a recoded nuclear gene inserted into yeast mitochondrial DNA is limited by mRNA-specific translational activation. Steele DF, et al. Proc Natl Acad Sci U S A, 1996 May 28. PMID 8643562, Free PMC Article
    3. The N-acetylglutamate synthase/N-acetylglutamate kinase metabolon of Saccharomyces cerevisiae allows co-ordinated feedback regulation of the first two steps in arginine biosynthesis. Pauwels K, et al. Eur J Biochem, 2003 Mar. PMID 12603335
    4. An antioxidative mechanism mediated by the yeast N-acetyltransferase Mpr1: oxidative stress-induced arginine synthesis and its physiological role. Nishimura A, et al. FEMS Yeast Res, 2010 Sep. PMID 20550582
    5. Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity. Resnick AC, et al. Proc Natl Acad Sci U S A, 2005 Sep 6. PMID 16123124, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-arginine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-arginine biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in arginine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ornithine biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    acetylornithine transaminase
    NP_014501.1
    • Acetylornithine aminotransferase; catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      58759..60030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183394.1 → NP_014501.1  TPA: acetylornithine transaminase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014501.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1S9, P18544
      UniProtKB/TrEMBL
      A6ZN72, B3LIS7, B5VRC1, C7GV15, C8ZHH7, G2WM98, N1NYC6
      Conserved Domains (1) summary
      TIGR00707
      Location:23 → 418
      argD; transaminase, acetylornithine/succinylornithine family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18544.1

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