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    NOP8 Nop8p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854021, updated on 7-Jul-2024

    Summary

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    Gene symbol
    NOP8
    Gene description
    Nop8p
    Primary source
    FungiDB:YOL144W
    Locus tag
    YOL144W
    See related
    SGD:S000005504; AllianceGenome:SGD:S000005504; VEuPathDB:YOL144W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ribonuclease inhibitor activity. Involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Orthologous to human NOL8 (nucleolar protein 8). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See NOP8 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (53098..54552)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene DNA replication protein PSF3 Neighboring gene Ctr9p Neighboring gene lumazine synthase RIB4 Neighboring gene exosome non-catalytic core subunit RRP40

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nip7p interacts with Nop8p, an essential nucleolar protein required for 60S ribosome biogenesis, and the exosome subunit Rrp43p. Zanchin NI, et al. Mol Cell Biol, 1999 Feb. PMID 9891085, Free PMC Article
    2. The essential nucleolar yeast protein Nop8p controls the exosome function during 60S ribosomal subunit maturation. Santos MC, et al. PLoS One, 2011. PMID 21747919, Free PMC Article
    3. Association of the GTP-binding protein Gtr1p with Rpc19p, a shared subunit of RNA polymerase I and III in yeast Saccharomyces cerevisiae. Todaka Y, et al. Genetics, 2005 Aug. PMID 15937128, Free PMC Article
    4. The putative RNA helicase Dbp6p functionally interacts with Rpl3p, Nop8p and the novel trans-acting Factor Rsa3p during biogenesis of 60S ribosomal subunits in Saccharomyces cerevisiae. de la Cruz J, et al. Genetics, 2004 Apr. PMID 15126390, Free PMC Article
    5. Cwc24p, a novel Saccharomyces cerevisiae nuclear ring finger protein, affects pre-snoRNA U3 splicing. Goldfeder MB, et al. J Biol Chem, 2008 Feb 1. PMID 17974558

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results support the idea that Npa2p, Dbp6p, Npa1p, Nop8p, and Rsa3p work in concert during the early steps of 60S subunit biogenesis.
      Title: Characterization of Saccharomyces cerevisiae Npa2p (Urb2p) reveals a low-molecular-mass complex containing Dbp6p, Npa1p (Urb1p), Nop8p, and Rsa3p involved in early steps of 60S ribosomal subunit biogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribonuclease inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nop8p
    NP_014497.1
    • Nucleolar protein required for 60S ribosomal subunit biogenesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      53098..54552
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183398.1 → NP_014497.1  TPA: Nop8p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014497.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1S5, Q08287
      UniProtKB/TrEMBL
      A0A8H4BVM2, B3LIS3, N1NY89
      Conserved Domains (1) summary
      cd12226
      Location:8 → 82
      RRM_NOL8; RNA recognition motif (RRM) found in nucleolar protein 8 (NOL8) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08287.1

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