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    HIR2 Hir2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854203, updated on 3-Nov-2024

    Summary

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    Official Symbol
    HIR2
    Official Full Name
    Hir2p
    Primary source
    SGD:S000005564
    Locus tag
    YOR038C
    See related
    AllianceGenome:SGD:S000005564; FungiDB:YOR038C; VEuPathDB:YOR038C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SPT1
    Summary
    Enables transcription corepressor activity. Contributes to DNA binding activity and nucleosome binding activity. Involved in negative regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase III; and transcription elongation-coupled chromatin remodeling. Located in cytosol and nucleus. Part of HIR complex. Orthologous to human HIRA (histone cell cycle regulator). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See HIR2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (402761..405388, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene SNAP receptor PEP12 Neighboring gene oxidoreductase Neighboring gene casein kinase 2 regulatory subunit CKB2 Neighboring gene hydroxyacylglutathione hydrolase GLO4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Subnuclear localization and mitotic phosphorylation of HIRA, the human homologue of Saccharomyces cerevisiae transcriptional regulators Hir1p/Hir2p. De Lucia F, et al. Biochem J, 2001 Sep 1. PMID 11513744, Free PMC Article
    2. Functional analysis of histones H2A and H2B in transcriptional repression in Saccharomyces cerevisiae. Recht J, et al. Mol Cell Biol, 1996 Jun. PMID 8649361, Free PMC Article
    3. A human homolog of the S. cerevisiae HIR1 and HIR2 transcriptional repressors cloned from the DiGeorge syndrome critical region. Lamour V, et al. Hum Mol Genet, 1995 May. PMID 7633437
    4. Characterization of HIR1 and HIR2, two genes required for regulation of histone gene transcription in Saccharomyces cerevisiae. Sherwood PW, et al. Mol Cell Biol, 1993 Jan. PMID 8417331, Free PMC Article
    5. Functional dissection of yeast Hir1p, a WD repeat-containing transcriptional corepressor. DeSilva H, et al. Genetics, 1998 Feb. PMID 9504914, Free PMC Article

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to nucleosome binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase III IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase III IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription elongation-coupled chromatin remodeling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of HIR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of HIR complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of HIR complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Hir2p
    NP_014681.1
    • Subunit of HIR nucleosome assembly complex; involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p; relocalizes to the cytosol in response to hypoxia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      402761..405388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183457.1 → NP_014681.1  TPA: Hir2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014681.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2A5, P32480
      UniProtKB/TrEMBL
      B3LJ91
      Conserved Domains (3) summary
      sd00039
      Location:123 → 163
      7WD40; WD40 repeat [structural motif]
      pfam07569
      Location:581 → 816
      Hira; TUP1-like enhancer of split
      cl29593
      Location:172 → 350
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32480.2

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