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    GYP1 GTPase-activating protein GYP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854236, updated on 17-May-2024

    Summary

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    Gene symbol
    GYP1
    Gene description
    GTPase-activating protein GYP1
    Primary source
    FungiDB:YOR070C
    Locus tag
    YOR070C
    See related
    SGD:S000005596; AllianceGenome:SGD:S000005596; VEuPathDB:YOR070C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YOR29-21
    Summary
    Enables GTPase activator activity. Involved in vesicle-mediated transport. Located in Golgi apparatus. Orthologous to human TBC1D22A (TBC1 domain family member 22A) and TBC1D22B (TBC1 domain family member 22B). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GYP1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (455907..457820, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase Neighboring gene Vam10p Neighboring gene sorting nexin 1 Neighboring gene nicotinamide riboside transporter Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the GAP domain of Gyp1p: first insights into interaction with Ypt/Rab proteins. Rak A, et al. EMBO J, 2000 Oct 2. PMID 11013213, Free PMC Article
    2. Identification and partial purification of GTPase-activating proteins from yeast and mammalian cells that preferentially act on Ypt1/Rab1 proteins. Tan TJ, et al. FEBS Lett, 1991 Oct 21. PMID 1936282
    3. A Rab prenyl membrane-anchor allows effector recognition to be regulated by guanine nucleotide. Lee M, et al. Proc Natl Acad Sci U S A, 2020 Apr 7. PMID 32213587, Free PMC Article
    4. Identification of regulators for Ypt1 GTPase nucleotide cycling. Jones S, et al. Mol Biol Cell, 1998 Oct. PMID 9763446, Free PMC Article
    5. Establishing a role for the GTPase Ypt1p at the late Golgi. Sclafani A, et al. Traffic, 2010 Apr. PMID 20059749, Free PMC Article

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gyp1 acts as a Ypt1 GTPase-activating protein (GAP) for selective autophagic variants, such as the Cvt pathway or the selective autophagic degradation of mitochondria (mitophagy). Gyp1 regulates the dynamic disassembly of the conserved Ypt1-Atg1 complex. Thereby, Gyp1 sets the stage for efficient Atg14 recruitment, and facilitates the critical step from nucleation to elongation of the phagophore.
      Title: Gyp1 has a dual function as Ypt1 GAP and interaction partner of Atg8 in selective autophagy.
    2. Ypt1p regulates the flow of traffic into the cis and trans side of the Golgi via multiple effectors.
      Title: Establishing a role for the GTPase Ypt1p at the late Golgi.
    3. Data show that Gyp1p, a GAP for Ypt1p, specifically interacts with Ypt32p, and that this interaction is important for the localization and stability of Gyp1p.
      Title: A Rab GAP cascade defines the boundary between two Rab GTPases on the secretory pathway.
    4. crystallographic, mutational and functional analyses of complexes between Rab GTPases and the TBC domain of Gyp1p
      Title: TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi stack IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    GTPase-activating protein GYP1
    NP_014713.1
    • Cis-golgi GTPase-activating protein (GAP) for yeast Rabs; the Rab family members are Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion; interacts with autophagosome component Atg8p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      455907..457820 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183489.1 → NP_014713.1  TPA: GTPase-activating protein GYP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014713.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2D3, O00028, Q08484
      UniProtKB/TrEMBL
      A0A8H4BUT8, B3LJB9, B5VRW8, C7GX48, C8ZI31, G2WMU8, N1NYB5
      Conserved Domains (1) summary
      COG5210
      Location:24 → 632
      COG5210; GTPase-activating protein [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08484.1

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