ARF3 Arf family GTPase ARF3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ARF3
Official Full Name: Arf family GTPase ARF3
Primary source: SGD:S000005620
Locus tag: YOR094W
See related: AllianceGenome:SGD:S000005620; FungiDB:YOR094W; VEuPathDB:YOR094W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ARL2
Summary: Enables GTPase activity; enzyme activator activity; and mRNA binding activity. Involved in several processes, including actin cortical patch localization; invasive growth in response to glucose limitation; and positive regulation of phosphatidylinositol biosynthetic process. Located in cellular bud neck and cellular bud tip. Orthologous to human ARF6 (ADP ribosylation factor 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ARF3 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (502795..503346)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here, the authors reconstitute a core tubulin chaperone consisting of tubulin cofactors Cin1, Pac2, and Arl2, and reveal a cage-like structure for regulating alphabeta-tubulin.
Title: Tubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble αβ-tubulin pool for microtubule dynamics.
direct Arf activation by Snf1 regulates cellular responses to energy deprivation, in particular invasive cell growth
Title: Snf1/AMP-activated protein kinase activates Arf3p to promote invasive yeast growth via a non-canonical GEF domain.
A novel spatial activation of Arf3p plays a role in regulating Bud2p activation during glucose depletion-induced invasive growth in Saccharomyces cerevisiae.
Title: Arf3p GTPase is a key regulator of Bud2p activation for invasive growth in Saccharomyces cerevisiae.
a role for ARF3 in cell polarity and the organization of the actin cytoskeleton
Title: The Saccharomyces cerevisiae Arf3 protein is involved in actin cable and cortical patch formation.
Afi1p functions as an Arf3p polarization-specific adapter and participates in development of polarity
Title: Afi1p functions as an Arf3p polarization-specific docking factor for development of polarity.
This study describes the role of Lsb5p in membrane-trafficking events at the plasma membrane and also demonstrate for the first time an interaction of Arf3 with the endocytic machinery in yeast.
Title: Lsb5p interacts with actin regulators Sla1p and Las17p, ubiquitin and Arf3p to couple actin dynamics to membrane trafficking processes.
ScARF1 and ScARF3 are the yeast orthologs of mammalian ARF1 and ARF6 and have roles in the control of peroxisome proliferation
Title: Binding and functions of ADP-ribosylation factor on mammalian and yeast peroxisomes.
Results discuss the interaction of Sla1p with Lsb5p, and demonstrate a requirement for Arf3p expression in order to localize Lsb5p to the cell cortex.
Title: Interactions between Sla1p, Lsb5p and Arf3p in yeast endocytosis.
Arf-like protein 2 interaction with PDEdelta is dependent on GTP, and the binding of PDEdelta substantially stabilizes GTP binding; data suggests that Arl2/3 are specific regulators of PDEdelta
Title: Properties of the interaction of Arf-like protein 2 with PDEdelta.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables enzyme activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cortical patch localization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in actin cortical patch localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament bundle assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular bud site selection	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in invasive filamentous growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in invasive growth in response to glucose limitation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Arf family GTPase ARF3

NP_014737.1

Glucose-repressible ADP-ribosylation factor; GTPase of Ras superfamily involved in regulating cell polarity and invasive growth; localizes to dynamic spots at plasma membrane and modulates PtdIns(4,5)P2 levels to facilitate endocytosis; required for localization of endocytic protein Lsb5p to correct cortical site in cells; also has mRNA binding activity; homolog of mammalian Arf6