RPT5 proteasome regulatory particle base subunit RPT5 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RPT5
Official Full Name: proteasome regulatory particle base subunit RPT5
Primary source: SGD:S000005643
Locus tag: YOR117W
See related: AllianceGenome:SGD:S000005643; FungiDB:YOR117W; VEuPathDB:YOR117W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: YTA1
Summary: Predicted to enable ATP hydrolysis activity and proteasome-activating activity. Involved in positive regulation of RNA polymerase II transcription preinitiation complex assembly; proteasome regulatory particle assembly; and ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle, base subcomplex. Orthologous to human PSMC3 (proteasome 26S subunit, ATPase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RPT5 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (545029..546333)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

show that Spt5 is needed for efficient splicing and for the accumulation of U5 snRNPs at intron-containing genes, and therefore for stable cotranscriptional assembly of spliceosomes
Title: Spt5 modulates cotranscriptional spliceosome assembly in Saccharomyces cerevisiae.
Rpt5 protein (Rpt5p)is a proteasome subunit with chaperone functions.
Title: The proteasome cap RPT5/Rpt5p subunit prevents aggregation of unfolded ricin A chain.
Loss of Rpt5 protein interactions with the core particle and Nas2 protein causes the formation of faulty proteasomes that are inhibited by Ecm29 protein.
Title: Loss of Rpt5 protein interactions with the core particle and Nas2 protein causes the formation of faulty proteasomes that are inhibited by Ecm29 protein.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables proteasome-activating activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macromolecule metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of proteasomal protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome regulatory particle assembly	IEA Inferred from Electronic Annotation more info
involved_in proteasome regulatory particle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome regulatory particle, base subcomplex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome regulatory particle, base subcomplex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome regulatory particle, base subcomplex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proteasome regulatory particle base subunit RPT5

NP_014760.3

ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

545029..546333

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183536.3 → NP_014760.3 TPA: proteasome regulatory particle base subunit RPT5 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014760.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2H6, P33297

UniProtKB/TrEMBL

A6ZNW5, B3LJG0, C7GML9, C8ZI79, G2WMZ3, N1NWL4

Conserved Domains (1) summary

COG1222
Location:5 → 434

RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]