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    ORT1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854297, updated on 22-Aug-2024

    Summary

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    Official Symbol
    ORT1
    Primary source
    FungiDB:YOR130C
    Locus tag
    YOR130C
    See related
    SGD:S000005656; AllianceGenome:SGD:S000005656; VEuPathDB:YOR130C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ARG11
    Summary
    Enables L-ornithine transmembrane transporter activity. Involved in arginine biosynthetic process and mitochondrial L-ornithine transmembrane transport. Located in mitochondrial envelope. Used to study ornithine translocase deficiency. Human ortholog(s) of this gene implicated in amino acid metabolic disorder; citrullinemia; and ornithine translocase deficiency. Orthologous to several human genes including SLC25A15 (solute carrier family 25 member 15). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (569929..570807, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene phosphoribosylaminoimidazole carboxylase ADE2 Neighboring gene Afi1p Neighboring gene tRNA-Asp Neighboring gene putative haloacid dehalogenase-like hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Heterologous Expression in Yeast of Human Ornithine Carriers ORNT1 and ORNT2 and of ORNT1 Alleles Implicated in HHH Syndrome in Humans. Doimo M, et al. JIMD Rep, 2016. PMID 26589310, Free PMC Article
    2. Pathogenic potential of SLC25A15 mutations assessed by transport assays and complementation of Saccharomyces cerevisiae ORT1 null mutant. Marobbio CM, et al. Mol Genet Metab, 2015 May. PMID 25818551
    3. A strong carbon source effect is mediated by pUC plasmid sequences in a series of classical yeast vectors designed for promoter characterization. Pauwels K, et al. Yeast, 1999 Sep 15. PMID 10487929
    4. Transport of arginine and ornithine into isolated mitochondria of Saccharomyces cerevisiae. Soetens O, et al. Eur J Biochem, 1998 Dec 1. PMID 9874237
    5. Identification of the yeast ARG-11 gene as a mitochondrial ornithine carrier involved in arginine biosynthesis. Palmieri L, et al. FEBS Lett, 1997 Jun 30. PMID 9237680

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables L-ornithine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-ornithine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in arginine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in arginine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial L-ornithine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial L-ornithine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ort1p
    NP_014773.4
    • Ornithine transporter of the mitochondrial inner membrane; exports ornithine from mitochondria as part of arginine biosynthesis; functionally complemented by human ortholog, SLC25A15, which is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome, but HHH-associated variants fail to complement

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      569929..570807 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183549.4 → NP_014773.4  TPA: Ort1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014773.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2I8, Q12375, Q92273
      UniProtKB/TrEMBL
      A6ZNX7, B3LJH2, B5VS20, C7GMK9, C8ZI92, G2WN05, N1NYG4
      Conserved Domains (1) summary
      pfam00153
      Location:103 → 200
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12375.2

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