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    BAG7 GTPase-activating protein BAG7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854302, updated on 2-Nov-2024

    Summary

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    Official Symbol
    BAG7
    Official Full Name
    GTPase-activating protein BAG7
    Primary source
    SGD:S000005660
    Locus tag
    YOR134W
    See related
    AllianceGenome:SGD:S000005660; FungiDB:YOR134W; VEuPathDB:YOR134W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTPase activator activity. Involved in negative regulation of Rho protein signal transduction. Predicted to be active in cell cortex. Orthologous to human GMIP (GEM interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See BAG7 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (578564..579793)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene retromer subunit VPS17 Neighboring gene elongation factor 2 Neighboring gene isocitrate dehydrogenase (NAD(+)) IDH2 Neighboring gene Sia1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of the Bag7, Lrg1 and Rgd2 RhoGAP proteins from Saccharomyces cerevisiae. Roumanie O, et al. FEBS Lett, 2001 Oct 5. PMID 11591390
    2. Lrg1p functions as a putative GTPase-activating protein in the Pkc1p-mediated cell integrity pathway in Saccharomyces cerevisiae. Lorberg A, et al. Mol Genet Genomics, 2001 Nov. PMID 11713681
    3. The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2. Schmidt A, et al. Cell, 1997 Feb 21. PMID 9038344
    4. The RHO1-GAPs SAC7, BEM2 and BAG7 control distinct RHO1 functions in Saccharomyces cerevisiae. Schmidt A, et al. Mol Microbiol, 2002 Sep. PMID 12207708
    5. Cadmium induces the activation of cell wall integrity pathway in budding yeast. Xiong B, et al. Chem Biol Interact, 2015 Oct 5. PMID 26362500

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Rho protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of fungal-type cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    GTPase-activating protein BAG7
    NP_014777.3
    • Rho GTPase activating protein (RhoGAP); stimulates the intrinsic GTPase activity of Rho1p, which plays a bud growth by regulating actin cytoskeleton organization and cell wall biosynthesis, resulting in the downregulation of Rho1p; structurally and functionally related to Sac7p; BAG7 has a paralog, SAC7, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      578564..579793
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183553.3 → NP_014777.3  TPA: GTPase-activating protein BAG7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014777.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2J2, Q12128
      UniProtKB/TrEMBL
      A6ZNY1, B3LJH6, B5VS23, C7GN87, C8ZI96, N1P368
      Conserved Domains (1) summary
      cd04396
      Location:47 → 257
      RhoGAP_fSAC7_BAG7; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12128.1

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