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    LIP5 putative lipoate synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854371, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LIP5
    Official Full Name
    putative lipoate synthase
    Primary source
    SGD:S000005722
    Locus tag
    YOR196C
    See related
    AllianceGenome:SGD:S000005722; FungiDB:YOR196C; VEuPathDB:YOR196C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable lipoate synthase activity. Involved in protein lipoylation. Located in mitochondrion. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human LIAS (lipoic acid synthetase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See LIP5 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (715593..716837, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene transcription initiation factor IIA large subunit Neighboring gene Slk19p Neighboring gene Ca(2+)-dependent cysteine protease MCA1 Neighboring gene Bfr1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alpha-Ketoglutarate dehydrogenase and lipoic acid synthase are important for the functioning of peroxisomes of Saccharomyces cerevisiae. Smaczyńska-de Rooij I, et al. Cell Mol Biol Lett, 2004. PMID 15213808
    2. Lipoic acid synthesis and attachment in yeast mitochondria. Schonauer MS, et al. J Biol Chem, 2009 Aug 28. PMID 19570983, Free PMC Article
    3. Functional Reconstitution of a Pyruvate Dehydrogenase in the Cytosol of Saccharomyces cerevisiae through Lipoylation Machinery Engineering. Lian J, et al. ACS Synth Biol, 2016 Jul 15. PMID 26991359
    4. Structural and mechanistic studies of VPS4 proteins. Scott A, et al. EMBO J, 2005 Oct 19. PMID 16193069, Free PMC Article
    5. Genetic analysis of desiccation tolerance in Sachharomyces cerevisiae. Calahan D, et al. Genetics, 2011 Oct. PMID 21840858, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results presented indicate that the alpha-ketoglutarate dehydrogenase complex and lipoic acid synthase are important for the proper functioning of peroxisomes.
      Title: Alpha-Ketoglutarate dehydrogenase and lipoic acid synthase are important for the functioning of peroxisomes of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipoate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipoate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipoate synthase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipoate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipoate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein lipoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein lipoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative lipoate synthase
    NP_014839.1
    • Protein involved in biosynthesis of the coenzyme lipoic acid; has similarity to E. coli lipoic acid synthase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      715593..716837 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183615.1 → NP_014839.1  TPA: putative lipoate synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014839.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZP42, B3LJM6, B5VS81, C7GWI3, C8ZGV5, D6W2Q5, P32875
      UniProtKB/TrEMBL
      G2WN71, N1NYL8
      Conserved Domains (1) summary
      TIGR00510
      Location:104 → 411
      lipA; lipoate synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32875.1

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