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    BFR1 Bfr1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854373, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BFR1
    Official Full Name
    Bfr1p
    Primary source
    SGD:S000005724
    Locus tag
    YOR198C
    See related
    AllianceGenome:SGD:S000005724; FungiDB:YOR198C; VEuPathDB:YOR198C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA binding activity. Involved in several processes, including protein O-linked mannosylation; protein insertion into ER membrane; and regulation of mitotic nuclear division. Located in endoplasmic reticulum and nuclear outer membrane-endoplasmic reticulum membrane network. Part of polysome. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See BFR1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (718653..720065, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene putative lipoate synthase Neighboring gene Ca(2+)-dependent cysteine protease MCA1 Neighboring gene Mrm1p Neighboring gene imidazoleglycerol-phosphate dehydratase HIS3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Local translation of yeast ERG4 mRNA at the endoplasmic reticulum requires the brefeldin A resistance protein Bfr1. Manchalu S, et al. RNA, 2019 Dec. PMID 31455610, Free PMC Article
    2. Both KH and non-KH domain sequences are required for polyribosome association of Scp160p in yeast. Li AM, et al. Nucleic Acids Res, 2004. PMID 15356294, Free PMC Article
    3. Yeast mutants that produce a novel type of ascus containing asci instead of spores. Xue Z, et al. Genetics, 1996 Nov. PMID 8913743, Free PMC Article
    4. mRNA localization to P-bodies in yeast is bi-phasic with many mRNAs captured in a late Bfr1p-dependent wave. Simpson CE, et al. J Cell Sci, 2014 Mar 15. PMID 24424022, Free PMC Article
    5. Inhibition of TATA binding protein dimerization by RNA polymerase III transcription initiation factor Brf1. Alexander DE, et al. J Biol Chem, 2004 Jul 30. PMID 15190063

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results identify Bfr1 affecting O-mannosylation through changes in Pmt1 and Pmt2 protein abundance but has no effect on PMT1 and PMT2 transcript levels, mRNA localization to the ER membrane or protein stability. Ribosome profiling reveals that Bfr1 is a crucial factor for Pmt1 and Pmt2 translation thereby affecting unfolded protein O-mannosylation.
      Title: Translational Regulation of Pmt1 and Pmt2 by Bfr1 Affects Unfolded Protein O-Mannosylation.
    2. Bfr1p is a latephaselocalizing Pbody protein that is important for the delayed entry of certain mRNAS to Pbodies.
      Title: mRNA localization to P-bodies in yeast is bi-phasic with many mRNAs captured in a late Bfr1p-dependent wave.
    3. Data propose that Bfr1p regulates the secretory pathway protein abundance levels in the presence of elevated ER stress and acts as a checkpoint in monitoring the levels of ER stress and the function of kinetochores before regulating its own levels.
      Title: Kinetochore genes are required to fully activate secretory pathway expansion in S. cerevisiae under induced ER stress.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding HDA PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to glucose starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular mRNA localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein O-linked mannosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein insertion into ER membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in nuclear outer membrane-endoplasmic reticulum membrane network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear outer membrane-endoplasmic reticulum membrane network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Bfr1p
    NP_014841.1
    • Component of mRNP complexes associated with polyribosomes; involved in localization of mRNAs to P bodies; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      718653..720065 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183617.1 → NP_014841.1  TPA: Bfr1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014841.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2Q7, P38934
      UniProtKB/TrEMBL
      A6ZP44, B5VS83, C7GWI1, C8ZGV7, G2WN73, N1P3E6
      Conserved Domains (1) summary
      COG1196
      Location:3 → 277
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38934.1

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