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    COT1 metal cation transporter COT1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854494, updated on 2-Nov-2024

    Summary

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    Official Symbol
    COT1
    Official Full Name
    metal cation transporter COT1
    Primary source
    SGD:S000005843
    Locus tag
    YOR316C
    See related
    AllianceGenome:SGD:S000005843; FungiDB:YOR316C; VEuPathDB:YOR316C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cobalt ion transmembrane transporter activity and zinc ion transmembrane transporter activity. Involved in cobalt ion transport; intracellular zinc ion homeostasis; and zinc ion transport. Located in fungal-type vacuole membrane and membrane raft. Human ortholog(s) of this gene implicated in hypermanganesemia with dystonia 1. Orthologous to several human genes including SLC30A1 (solute carrier family 30 member 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See COT1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (906236..907555, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Sfg1p Neighboring gene uncharacterized protein Neighboring gene long-chain fatty acid-CoA ligase FAA1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. COT1, a gene involved in cobalt accumulation in Saccharomyces cerevisiae. Conklin DS, et al. Mol Cell Biol, 1992 Sep. PMID 1508175, Free PMC Article
    2. The Genome Sequence of the Jean-Talon Strain, an Archeological Beer Yeast from Québec, Reveals Traces of Adaptation to Specific Brewing Conditions. Fijarczyk A, et al. G3 (Bethesda), 2020 Sep 2. PMID 32605927, Free PMC Article
    3. Dithizone staining of intracellular zinc: an unexpected and versatile counterscreen for auxotrophic marker genes in Saccharomyces cerevisiae. Yuan DS. PLoS One, 2011. PMID 21998704, Free PMC Article
    4. Biochemical properties of vacuolar zinc transport systems of Saccharomyces cerevisiae. MacDiarmid CW, et al. J Biol Chem, 2002 Oct 18. PMID 12161436
    5. The plant CDF family member TgMTP1 from the Ni/Zn hyperaccumulator Thlaspi goesingense acts to enhance efflux of Zn at the plasma membrane when expressed in Saccharomyces cerevisiae. Kim D, et al. Plant J, 2004 Jul. PMID 15225288

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zrc1 and Cot1 vacuolar zinc transporters control alkaline phosphatase accumulation and activity.
      Title: Zinc status and vacuolar zinc transporters control alkaline phosphatase accumulation and activity in Saccharomyces cerevisiae.
    2. analysis of how one single amino acid change in the yeast vacuolar metal transporters ZRC1 and COT1 alters their substrate specificity
      Title: A single amino acid change in the yeast vacuolar metal transporters ZRC1 and COT1 alters their substrate specificity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cobalt ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cobalt ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inorganic ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular monoatomic cation homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular zinc ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular zinc ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in zinc ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    metal cation transporter COT1
    NP_014961.3
    • Vacuolar transporter that mediates zinc transport into vacuole; overexpression confers resistance to cobalt and rhodium; targeted to vacuole via AP-3 pathway; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      906236..907555 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183736.3 → NP_014961.3  TPA: metal cation transporter COT1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014961.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W314, P32798
      UniProtKB/TrEMBL
      B5VSJ1, C7GNU7, N1NXG6
      Conserved Domains (1) summary
      COG1230
      Location:9 → 384
      CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32798.2

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