MFM1 Mfm1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MFM1
Official Full Name: Mfm1p
Primary source: SGD:S000005981
Locus tag: YPL060W
See related: AllianceGenome:SGD:S000005981; FungiDB:YPL060W; VEuPathDB:YPL060W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: LPE10
Summary: Enables magnesium ion transmembrane transporter activity. Involved in mitochondrial magnesium ion transmembrane transport. Located in mitochondrial inner membrane. Orthologous to human MRS2 (magnesium transporter MRS2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MFM1 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (434523..435764)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The interplay of Lpe10p is of central significance for the transport of Mg(2+) into mitochondria of S. cerevisiae.
Title: Lpe10p modulates the activity of the Mrs2p-based yeast mitochondrial Mg2+ channel.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables magnesium ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables magnesium ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in mitochondrial magnesium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial magnesium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Mfm1p

NP_015265.1

Mitochondrial inner membrane magnesium transporter; involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

434523..435764

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183874.1 → NP_015265.1 TPA: Mfm1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015265.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W3V4, Q02783, Q6B1B1

UniProtKB/TrEMBL

C7GTZ6, G2WPB9

Conserved Domains (1) summary

cd12823
Location:74 → 395

Mrs2_Mfm1p-like; Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family