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    SEC62 Sec63 complex subunit SEC62 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856011, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SEC62
    Official Full Name
    Sec63 complex subunit SEC62
    Primary source
    SGD:S000006015
    Locus tag
    YPL094C
    See related
    AllianceGenome:SGD:S000006015; FungiDB:YPL094C; VEuPathDB:YPL094C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LPG14
    Summary
    Enables protein transmembrane transporter activity. Involved in post-translational protein targeting to membrane, translocation. Located in endoplasmic reticulum. Part of Sec62/Sec63 complex. Orthologous to human SEC62 (SEC62 homolog, preprotein translocation factor). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See SEC62 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (369839..370663, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase Neighboring gene medium-chain fatty acid ethyl ester synthase/esterase Neighboring gene putative GTPase NOG1 Neighboring gene Ssu1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SEC62 encodes a putative membrane protein required for protein translocation into the yeast endoplasmic reticulum. Deshaies RJ, et al. J Cell Biol, 1989 Dec. PMID 2687286, Free PMC Article
    2. Endoplasmic reticulum-resident protein Sec62 drives colorectal cancer metastasis via MAPK/ATF2/UCA1 axis. Jin Y, et al. Cell Prolif, 2022 Dec. PMID 36200182, Free PMC Article
    3. Expression level of Sec62 modulates membrane insertion of marginally hydrophobic segments. Jung SJ, et al. Biochim Biophys Acta Biomembr, 2022 Dec 1. PMID 36122759
    4. Yeast Sec proteins interact with polypeptides traversing the endoplasmic reticulum membrane. Müsch A, et al. Cell, 1992 Apr 17. PMID 1568249
    5. Structural and functional dissection of Sec62p, a membrane-bound component of the yeast endoplasmic reticulum protein import machinery. Deshaies RJ, et al. Mol Cell Biol, 1990 Nov. PMID 2233730, Free PMC Article

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endoplasmic reticulum-resident protein Sec62 drives colorectal cancer metastasis via MAPK/ATF2/UCA1 axis.
      Title: Endoplasmic reticulum-resident protein Sec62 drives colorectal cancer metastasis via MAPK/ATF2/UCA1 axis.
    2. Expression level of Sec62 modulates membrane insertion of marginally hydrophobic segments.
      Title: Expression level of Sec62 modulates membrane insertion of marginally hydrophobic segments.
    3. Effect of Sec62 on the conformation of the Sec61 channel in yeast.
      Title: Effect of Sec62 on the conformation of the Sec61 channel in yeast.
    4. Architecture of the active post-translational Sec translocon.
      Title: Architecture of the active post-translational Sec translocon.
    5. Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62.
      Title: Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62.
    6. Data indicate that defect in Sec62 selectively reduced signal sequences inserted in an N(in)-C(out) (type II) membrane topology.
      Title: Sec62 protein mediates membrane insertion and orientation of moderately hydrophobic signal anchor proteins in the endoplasmic reticulum (ER).
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in post-translational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-translational protein targeting to membrane, translocation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Sec62/Sec63 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sec63 complex subunit SEC62
    NP_015231.2
    • Essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; cotranslationally N-acetylated by NatA; other members are Sec63p, Sec66p, and Sec72p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      369839..370663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183908.1 → NP_015231.2  TPA: Sec63 complex subunit SEC62 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015231.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3S3, P21825
      UniProtKB/TrEMBL
      A6ZWF7, B3LKX9, C7GJ48, G2WP87, N1NVH1
      Conserved Domains (1) summary
      COG5232
      Location:1 → 259
      SEC62; Preprotein translocase subunit Sec62 [Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21825.2

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