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    IDI1 isopentenyl-diphosphate delta-isomerase IDI1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855986, updated on 2-Nov-2024

    Summary

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    Official Symbol
    IDI1
    Official Full Name
    isopentenyl-diphosphate delta-isomerase IDI1
    Primary source
    SGD:S000006038
    Locus tag
    YPL117C
    See related
    AllianceGenome:SGD:S000006038; FungiDB:YPL117C; VEuPathDB:YPL117C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    BOT2; LPH10
    Summary
    Enables isopentenyl-diphosphate delta-isomerase activity. Involved in ergosterol biosynthetic process and farnesyl diphosphate biosynthetic process. Located in cytosol and nucleus. Used to study cancer. Orthologous to several human genes including IDI2 (isopentenyl-diphosphate delta isomerase 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See IDI1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (327864..328730, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene putative DEAD-box ATP-dependent RNA helicase DBP1 Neighboring gene mitochondrial 37S ribosomal protein MRP51 Neighboring gene histone deacetylase Neighboring gene GTPase-activating protein BEM3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isopentenyl-diphosphate isomerase: irreversible inhibition by 3-methyl-3,4-epoxybutyl diphosphate. Lu XJ, et al. Biochemistry, 1992 Oct 20. PMID 1390779
    2. Disruption and mapping of IDI1, the gene for isopentenyl diphosphate isomerase in Saccharomyces cerevisiae. Mayer MP, et al. Yeast, 1992 Sep. PMID 1441751
    3. Isopentenyldiphosphate:dimethylallyldiphosphate isomerase: construction of a high-level heterologous expression system for the gene from Saccharomyces cerevisiae and identification of an active-site nucleophile. Street IP, et al. Biochemistry, 1990 Aug 14. PMID 2223785
    4. Isopentenyl diphosphate:dimethylallyl diphosphate isomerase. An improved purification of the enzyme and isolation of the gene from Saccharomyces cerevisiae. Anderson MS, et al. J Biol Chem, 1989 Nov 15. PMID 2681212
    5. Mechanism of action of isopentenyl pyrophosphate isomerase: evidence for a carbonium ion intermediate. Reardon JE, et al. Biochemistry, 1986 Sep 23. PMID 3022798

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isopentenyl-diphosphate delta-isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables isopentenyl-diphosphate delta-isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables isopentenyl-diphosphate delta-isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dimethylallyl diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ergosterol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in farnesyl diphosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in isopentenyl diphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in nucleus HDA PubMed 
    is_active_in vacuole NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    isopentenyl-diphosphate delta-isomerase IDI1
    NP_015208.1
    • Isopentenyl diphosphate:dimethylallyl diphosphate isomerase; catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability; isopentenyl diphosphate:dimethylallyl diphosphate isomerase is also known as IPP isomerase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      327864..328730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183931.1 → NP_015208.1  TPA: isopentenyl-diphosphate delta-isomerase IDI1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015208.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3Q1, P15496
      UniProtKB/TrEMBL
      A6ZWD5, B5VT49, C7GJ70, C8ZIR3, G2WP65, N1NW25
      Conserved Domains (1) summary
      COG1443
      Location:69 → 281
      Idi; Isopentenyldiphosphate isomerase [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15496.2

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