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    TFB2 TFIIH/NER complex subunit TFB2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855981, updated on 7-Jul-2024

    Summary

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    Gene symbol
    TFB2
    Gene description
    TFIIH/NER complex subunit TFB2
    Primary source
    FungiDB:YPL122C
    Locus tag
    YPL122C
    See related
    SGD:S000006043; AllianceGenome:SGD:S000006043; VEuPathDB:YPL122C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables double-stranded DNA binding activity. Involved in nucleotide-excision repair; phosphorylation of RNA polymerase II C-terminal domain; and transcription by RNA polymerase II. Part of nucleotide-excision repair factor 3 complex; transcription factor TFIIH core complex; and transcription factor TFIIH holo complex. Orthologous to human GTF2H4 (general transcription factor IIH subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TFB2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (319226..320767, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Spc29p Neighboring gene ribonuclease T2 Neighboring gene Mei5p Neighboring gene beclin 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure determination of the minimal complex between Tfb5 and Tfb2, two subunits of the yeast transcription/DNA-repair factor TFIIH: a retrospective study. Kainov DE, et al. Acta Crystallogr D Biol Crystallogr, 2010 Jul. PMID 20606254
    2. Tfb5 interacts with Tfb2 and facilitates nucleotide excision repair in yeast. Zhou Y, et al. Nucleic Acids Res, 2007. PMID 17215295, Free PMC Article
    3. Interacting partners of the Tfb2 subunit from yeast TFIIH. Kainov DE, et al. DNA Repair (Amst), 2010 Jan 2. PMID 19897425
    4. Nucleotide excision repair in yeast. Prakash S, et al. Mutat Res, 2000 Jun 30. PMID 10915862
    5. Ubiquitin ligase activity of TFIIH and the transcriptional response to DNA damage. Takagi Y, et al. Mol Cell, 2005 Apr 15. PMID 15837426

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Comparison of the two structures revealed that the N-terminal region of Tfb2C and (to a lesser extent) the C-terminal region of Tfb5 contributed to the crystal packing.
      Title: Structure determination of the minimal complex between Tfb5 and Tfb2, two subunits of the yeast transcription/DNA-repair factor TFIIH: a retrospective study.
    2. found that Tfb2 bridges the Ssl2 helicase and the nucleotide excision DNA repair pathway-specific Tfb5 subunit.
      Title: Interacting partners of the Tfb2 subunit from yeast TFIIH.
    3. Tfb5 was found to interact with the core TFIIH subunit Tfb2.
      Title: Tfb5 interacts with Tfb2 and facilitates nucleotide excision repair in yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of nucleotide-excision repair factor 3 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIH core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIH core complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIIH core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIH holo complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIH holo complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TFIIH/NER complex subunit TFB2
    NP_015203.1
    • Subunit of TFIIH and nucleotide excision repair factor 3 complexes; involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      319226..320767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183936.1 → NP_015203.1  TPA: TFIIH/NER complex subunit TFB2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015203.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3P5, P87331, Q02939
      UniProtKB/TrEMBL
      A0A6A5Q2X3, A6ZWD0, B3LKV2, C7GJ76, C8ZIQ7, G2WP59, N1P1I8
      Conserved Domains (1) summary
      cl04289
      Location:9 → 510
      Tfb2; Transcription factor Tfb2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02939.1

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