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    DIM1 putative dimethyladenosine transferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855862, updated on 1-Aug-2024

    Summary

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    Gene symbol
    DIM1
    Gene description
    putative dimethyladenosine transferase
    Primary source
    FungiDB:YPL266W
    Locus tag
    YPL266W
    See related
    SGD:S000006187; AllianceGenome:SGD:S000006187; VEuPathDB:YPL266W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CDH1
    Summary
    Predicted to enable rRNA (adenine-N6,N6-)-dimethyltransferase activity. Involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and rRNA modification. Part of preribosome, small subunit precursor. Orthologous to human DIMT1 (DIM1 rRNA methyltransferase and ribosome maturation factor). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See DIM1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (39121..40077)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol phospholipase C Neighboring gene Acm1p Neighboring gene dicarboxylic amino acid permease Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of translation by methylation multiplicity of 18S rRNA. Liu K, et al. Cell Rep, 2021 Mar 9. PMID 33691096, Free PMC Article
    2. Toehold-enhanced LNA probes for selective pull down and single-molecule analysis of native chromatin. Hermans N, et al. Sci Rep, 2017 Dec 1. PMID 29196662, Free PMC Article
    3. Comprehensive phylogenetic analysis of evolutionarily conserved rRNA adenine dimethyltransferase suggests diverse bacterial contributions to the nucleus-encoded plastid proteome. Park AK, et al. Mol Phylogenet Evol, 2009 Feb. PMID 19017544
    4. Sequence and structural evolution of the KsgA/Dim1 methyltransferase family. O'Farrell HC, et al. BMC Res Notes, 2008 Oct 29. PMID 18959795, Free PMC Article
    5. Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis? Lafontaine DL, et al. Mol Cell Biol, 1998 Apr. PMID 9528805, Free PMC Article

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An open interface in the pre-80S ribosome coordinated by ribosome assembly factors Tsr1 and Dim1 enables temporal regulation of Fap7.
      Title: An open interface in the pre-80S ribosome coordinated by ribosome assembly factors Tsr1 and Dim1 enables temporal regulation of Fap7.
    2. During 40S ribosome biogenesis Fap7 links formation of a translation intermediate to release of the assembly factor Dim1. Bypassing Fap7 increases frameshifting.
      Title: The ATPase Fap7 Tests the Ability to Carry Out Translocation-like Conformational Changes and Releases Dim1 during 40S Ribosome Maturation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (adenine-N6,N6-)-dimethyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA (adenine-N6,N6-)-dimethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (adenine-N6,N6-)-dimethyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of 90S preribosome HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative dimethyladenosine transferase
    NP_015057.1
    • Essential 18S rRNA dimethylase (dimethyladenosine transferase); responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing; human homolog DIMT1 complements yeast dim1 mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      39121..40077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184080.1 → NP_015057.1  TPA: putative dimethyladenosine transferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015057.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3A4, P41819
      UniProtKB/TrEMBL
      A6ZVZ0, B3LKG7, C7GSG6, C8ZIB3, G2WNS0, N1NY06
      Conserved Domains (1) summary
      cl17173
      Location:28 → 317
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41819.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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