HOS1 histone deacetylase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: HOS1
Gene description: histone deacetylase
Primary source: FungiDB:YPR068C
Locus tag: YPR068C
See related: SGD:S000006272; AllianceGenome:SGD:S000006272; VEuPathDB:YPR068C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CST3
Summary: Enables protein deacetylase activity. Involved in protein deacetylation and regulation of gene expression. Part of histone deacetylase complex. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 5 and Wilson-Turner syndrome. Orthologous to human HDAC8 (histone deacetylase 8). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See HOS1 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (682941..684353, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Smc3 deacetylation by Hos1, triggered by Scc1 cleavage, facilitates efficient dissolution of sister chromatid cohesion during early metaphase.
Title: Smc3 Deacetylation by Hos1 Facilitates Efficient Dissolution of Sister Chromatid Cohesion during Early Anaphase.
Hos1 deacetylates Smc3 to close the cohesin acetylation cycle.
Title: Hos1 deacetylates Smc3 to close the cohesin acetylation cycle.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables histone deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables protein lysine deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein lysine deacetylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in epigenetic regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Rpd3L-Expanded complex	IBA Inferred from Biological aspect of Ancestor more info
part_of histone deacetylase complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histone deacetylase

NP_015393.1

EC 3.5.1.98

Class I histone deacetylase (HDAC) family member; deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

682941..684353 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184165.1 → NP_015393.1 TPA: histone deacetylase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015393.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W472, Q12214

UniProtKB/TrEMBL

A0A8H4BUF0, B3LLC1, C7GY52, C8ZJ93, N1NWD0

Conserved Domains (1) summary

cd11680
Location:5 → 390

HDAC_Hos1; Class I histone deacetylases Hos1 and related proteins