PRE2 proteasome core particle subunit beta 5 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: PRE2
Gene description: proteasome core particle subunit beta 5
Primary source: FungiDB:YPR103W
Locus tag: YPR103W
See related: SGD:S000006307; AllianceGenome:SGD:S000006307; VEuPathDB:YPR103W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: DOA3; PRG1; SRR2
Summary: Enables endopeptidase activity. Involved in proteasomal ubiquitin-independent protein catabolic process; proteasome core complex assembly; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytosol and nucleus. Part of proteasome core complex, beta-subunit complex. Human ortholog(s) of this gene implicated in JMP syndrome. Orthologous to several human genes including PSMB5 (proteasome 20S subunit beta 5) and PSMB8 (proteasome 20S subunit beta 8). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PRE2 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (732349..733212)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of the N-terminal half of the beta5 propeptide causes substantial defects in proteasome assembly.
Title: Distinct Elements in the Proteasomal β5 Subunit Propeptide Required for Autocatalytic Processing and Proteasome Assembly.
Data suggest regulated process for removal of proteasomes upon nitrogen starvation; autophagy involves separate processes for dissociation and nuclear export of core (PRE2) and regulatory (RPN1) proteins; only core protein autophagy depends on UBP3.
Title: Starvation Induces Proteasome Autophagy with Different Pathways for Core and Regulatory Particles.
Data indicate that the dynamic gate can be opened by allosteric coupling to a tetrahedral transition state at any of the working active centers of proteasome.
Title: A tetrahedral transition state at the active sites of the 20S proteasome is coupled to opening of the alpha-ring channel.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables threonine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteasomal ubiquitin-independent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasomal ubiquitin-independent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome core complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex, beta-subunit complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex, beta-subunit complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex, beta-subunit complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proteasome core particle subunit beta 5

NP_015428.1

EC 3.4.25.1

Beta 5 subunit of the 20S proteasome; responsible for the chymotryptic activity of the proteasome; localizes to peroxisomes in oleate-growing cells

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

732349..733212

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184200.1 → NP_015428.1 TPA: proteasome core particle subunit beta 5 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015428.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W4A1, P30656

UniProtKB/TrEMBL

A0A6A5Q5W3, A6ZWY3, B3LK67, B5VTP4, C7GXR4, C8ZJC5, G2WPR9, N1NVK9

Conserved Domains (1) summary

cd03761
Location:76 → 264

proteasome_beta_type_5; proteasome beta type-5 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...