TAZ1 lysophosphatidylcholine acyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: TAZ1
Gene description: lysophosphatidylcholine acyltransferase
Primary source: FungiDB:YPR140W
Locus tag: YPR140W
See related: SGD:S000006344; AllianceGenome:SGD:S000006344; VEuPathDB:YPR140W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables 1-acylglycerophosphocholine O-acyltransferase activity. Involved in mitochondrial ATP synthesis coupled electron transport; mitochondrion organization; and phospholipid metabolic process. Located in mitochondrial inner membrane and mitochondrial outer membrane. Is integral component of mitochondrial outer membrane. Used to study Barth syndrome. Human ortholog(s) of this gene implicated in Barth syndrome and dilated cardiomyopathy. Orthologous to human TAFAZZIN (tafazzin, phospholipid-lysophospholipid transacylase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See TAZ1 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (814391..815536)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bat1 and Bat2 are multi-copy suppressors of retarded growth of taz1 lacking yeast cells. Overexpression of Bat1/2 in taz1 lacking cells does not rescue known mitochondrial defects.
Title: Overexpression of branched-chain amino acid aminotransferases rescues the growth defects of cells lacking the Barth syndrome-related gene TAZ1.
The acyl specificity of tafazzin may be one of the factors that determine the acyl composition of mature Cardiolipin in S. cerevisiae mitochondria.
Title: Mechanism for Remodeling of the Acyl Chain Composition of Cardiolipin Catalyzed by Saccharomyces cerevisiae Tafazzin.
Taz1p is imported and sorted into the outer mitochondrial membrane via a membrane anchor domain.
Title: The Taz1p transacylase is imported and sorted into the outer mitochondrial membrane via a membrane anchor domain.
defective growth and respiration in tafazzin-deficient cells are caused by the decreased CL/MLCL ratio and not by a deficiency in unsaturated CL.
Title: Deletion of the cardiolipin-specific phospholipase Cld1 rescues growth and life span defects in the tafazzin mutant: implications for Barth syndrome.
Data indicate that monolysocardiolipin generated by Cld1p must be transported to intermembrane space (IMS)-facing membrane leaflets to gain access to tafazzin (TAZ1) for cardiolipin (CL) remodeling.
Title: Deacylation on the matrix side of the mitochondrial inner membrane regulates cardiolipin remodeling.
There is increased oxidative stress in the taz1Delta mutant during respiratory growth.
Title: Loss of tafazzin in yeast leads to increased oxidative stress during respiratory growth.
The yeast protein Ypr140w was expressed in E. coli, and a lyso-PC acyltransferase activity was found associated with the bacterial membranes.
Title: Ypr140wp, 'the yeast tafazzin', displays a mitochondrial lysophosphatidylcholine (lyso-PC) acyltransferase activity related to triacylglycerol and mitochondrial lipid synthesis.
We conclude that inactivation of Taz1 affects both assembly and stability of respiratory chain complexes in the inner membrane of mitochondria.
Title: Taz1, an outer mitochondrial membrane protein, affects stability and assembly of inner membrane protein complexes: implications for Barth Syndrome.
Barth syndrome (BTHS) can be caused by mutations that alter Taz1p sorting and assembly within the mitochondrion, indicating that the lipid target of Taz1p is resident to intermembrane space (IMS)-facing leaflets.
Title: Mitochondrial mislocalization and altered assembly of a cluster of Barth syndrome mutant tafazzins.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 1-acylglycerophosphocholine O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-acylglycerophosphocholine O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-acylglycerophosphocholine O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables 1-acylglycerophosphocholine O-acyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cardiolipin acyl-chain remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiolipin acyl-chain remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in cardiolipin acyl-chain remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiolipin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inner mitochondrial membrane organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in inner mitochondrial membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial ATP synthesis coupled electron transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial respirasome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lysophosphatidylcholine acyltransferase

NP_015466.1

Lyso-phosphatidylcholine acyltransferase; required for normal phospholipid content of mitochondrial membranes; major determinant of the final acyl chain composition of the mitochondrial-specific phospholipid cardiolipin; mutations in human ortholog tafazzin (TAZ) cause Barth syndrome, a rare X-linked disease characterized by skeletal and cardiomyopathy and bouts of cyclic neutropenia; a specific splice variant of human TAZ can complement yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

814391..815536

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184237.1 → NP_015466.1 TPA: lysophosphatidylcholine acyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015466.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W4D8, Q06510, Q6B2J1

UniProtKB/TrEMBL

A0A8H4BU87, A6ZX17, B3LKA1, B5VTS7, C8ZJG3, N1NWI7

Conserved Domains (1) summary

cd07989
Location:41 → 282

LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like