ASN1 asparagine synthase (glutamine-hydrolyzing) 1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ASN1
Official Full Name: asparagine synthase (glutamine-hydrolyzing) 1
Primary source: SGD:S000006349
Locus tag: YPR145W
See related: AllianceGenome:SGD:S000006349; FungiDB:YPR145W; VEuPathDB:YPR145W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables asparagine synthase (glutamine-hydrolyzing) activity. Involved in asparagine biosynthetic process. Located in cytoplasm. Orthologous to human ASNS (asparagine synthetase (glutamine-hydrolyzing)). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ASN1 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (822620..824338)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ASNS disruption shortens CTPS cytoophidia in Saccharomyces cerevisiae.
Title: ASNS disruption shortens CTPS cytoophidia in Saccharomyces cerevisiae.
Nuclear targeted Saccharomyces cerevisiae asparagine synthetases associate with the mitotic spindle regardless of their enzymatic activity.
Title: Nuclear targeted Saccharomyces cerevisiae asparagine synthetases associate with the mitotic spindle regardless of their enzymatic activity.
We show that ASN1D330V promotes filamentation. The ASN1D330V mutation impedes cell growth in an ASN2 knockout background, while growing normally in an ASN2 wild-type background.
Title: Filamentation of asparagine synthetase in Saccharomyces cerevisiae.
Analysis of highly expressed alleles on each background suggested ASN1 as a candidate transcript underlying nitrogen consumption differences between two strains.
Title: Natural variation in non-coding regions underlying phenotypic diversity in budding yeast.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables asparagine synthase (glutamine-hydrolyzing) activity	IBA Inferred from Biological aspect of Ancestor more info
enables asparagine synthase (glutamine-hydrolyzing) activity	IDA Inferred from Direct Assay more info	PubMed
enables asparagine synthase (glutamine-hydrolyzing) activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-asparagine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in asparagine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in asparagine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in asparagine biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glutamine metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: asparagine synthase (glutamine-hydrolyzing) 1

NP_015471.1

EC 6.3.5.4

Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN1 has a paralog, ASN2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

822620..824338

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184242.1 → NP_015471.1 TPA: asparagine synthase (glutamine-hydrolyzing) 1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015471.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W4E2, P49089

UniProtKB/TrEMBL

A6ZX21, B3LKA5, B5VTT1, C7GXT2, C8ZJG8, G2WPV8, N1P2F7

Conserved Domains (1) summary

PRK09431
Location:1 → 562

asnB; asparagine synthetase B; Provisional