SKI3 SKI complex subunit tetratricopeptide repeat protein SKI3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SKI3
Official Full Name: SKI complex subunit tetratricopeptide repeat protein SKI3
Primary source: SGD:S000006393
Locus tag: YPR189W
See related: AllianceGenome:SGD:S000006393; FungiDB:YPR189W; VEuPathDB:YPR189W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SKI5
Summary: Involved in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay and nuclear-transcribed mRNA catabolic process, non-stop decay. Part of Ski complex. Used to study trichohepatoenteric syndrome 1. Human ortholog(s) of this gene implicated in trichohepatoenteric syndrome 1. Orthologous to human SKIC3 (SKI3 subunit of superkiller complex). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See SKI3 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (912664..916962)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ski2, Ski3, and Ski8 assemble in a tetramer with 1:1:2 stoichiometry; 370 kDa core complex shows that Ski3 forms an array of 33 tetratricopeptide repeat motifs organized in N-terminal and C-terminal arms. The C-terminal arm of Ski3 and the two Ski8 subunits position the helicase core of Ski2 centrally within the complex, enhancing RNA binding.
Title: The yeast ski complex: crystal structure and RNA channeling to the exosome complex.
Ski3p serves as a scaffold protein with its C terminus interacting with Ski8p, and the sub-C terminus interacting with Ski2p.
Title: Domain interactions within the Ski2/3/8 complex and between the Ski complex and Ski7p.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in RNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in nuclear-transcribed mRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process, non-stop decay	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Ski complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Ski complex	IDA Inferred from Direct Assay more info	PubMed
part_of Ski complex	IEA Inferred from Electronic Annotation more info
part_of Ski complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SKI complex subunit tetratricopeptide repeat protein SKI3

NP_015515.1

Ski complex component and TPR protein; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; role in preventing L-A mycovirus pathogenesis; mutations in the human ortholog, TTC37, causes Syndromic diarrhea/Trichohepatoenteric (SD/THE) syndrome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

912664..916962

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184286.1 → NP_015515.1 TPA: SKI complex subunit tetratricopeptide repeat protein SKI3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015515.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P17883, Q06585

UniProtKB/TrEMBL

A6ZX63, B3LKE8, C7GP70, C8ZJL8

Conserved Domains (3) summary

TIGR02917
Location:412 → 836

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:735 → 765

TPR; TPR repeat [structural motif]

pfam18833
Location:151 → 241

TPR_22; Tetratricopeptide repeat