U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    NVJ2 Nvj2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856207, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    NVJ2
    Official Full Name
    Nvj2p
    Primary source
    SGD:S000006295
    Locus tag
    YPR091C
    See related
    AllianceGenome:SGD:S000006295; FungiDB:YPR091C; VEuPathDB:YPR091C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables lipid binding activity. Predicted to be involved in lipid transport. Located in nucleus-vacuole junction. Orthologous to human TEX2 (testis expressed 2). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See NVJ2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (716156..718468, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene RNA-binding signal recognition particle subunit SRP54 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. An inducible ER-Golgi tether facilitates ceramide transport to alleviate lipotoxicity. Liu LK, et al. J Cell Biol, 2017 Jan 2. PMID 28011845, Free PMC Article
    2. Homology of SMP domains to the TULIP superfamily of lipid-binding proteins provides a structural basis for lipid exchange between ER and mitochondria. Kopec KO, et al. Bioinformatics, 2010 Aug 15. PMID 20554689, Free PMC Article
    3. The vacuole controls nucleolar dynamics and micronucleophagy via the NVJ. Tasnin MN, et al. Biochem Biophys Res Commun, 2021 Apr 23. PMID 33706099
    4. Lipid droplet biogenesis is spatially coordinated at ER-vacuole contacts under nutritional stress. Hariri H, et al. EMBO Rep, 2018 Jan. PMID 29146766, Free PMC Article
    5. A conserved membrane-binding domain targets proteins to organelle contact sites. Toulmay A, et al. J Cell Sci, 2012 Jan 1. PMID 22250200, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables lipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ER to Golgi ceramide transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrion-endoplasmic reticulum membrane tethering IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ERMES complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell periphery HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus-vacuole junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Nvj2p
    NP_015416.1
    • Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); involved in nonvesicular transfer of ceramides from ER to Golgi during ER stress; may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial-lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      716156..718468 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184188.1 → NP_015416.1  TPA: Nvj2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015416.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W491, Q06833
      UniProtKB/TrEMBL
      B3LK58, N1P288
      Conserved Domains (1) summary
      cl17171
      Location:129 → 264
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06833.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools