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    CEX1 Cex1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854279, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CEX1
    Official Full Name
    Cex1p
    Primary source
    SGD:S000005638
    Locus tag
    YOR112W
    See related
    AllianceGenome:SGD:S000005638; FungiDB:YOR112W; VEuPathDB:YOR112W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables tRNA binding activity. Involved in tRNA export from nucleus. Acts upstream of or within retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in cytoplasm. Part of nuclear pore. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 21. Orthologous to several human genes including SCYL1 (SCY1 like pseudokinase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See CEX1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (531508..533793)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene transcription factor TFIIIC subunit TFC7 Neighboring gene nucleotide diphosphatase Neighboring gene Azf1p Neighboring gene mitochondrial HMG-box protein CIM1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein kinase A is part of a mechanism that regulates nuclear reimport of the nuclear tRNA export receptors Los1p and Msn5p. Pierce JB, et al. Eukaryot Cell, 2014 Feb. PMID 24297441, Free PMC Article
    2. Cex1p facilitates Rna1p-mediated dissociation of the Los1p-tRNA-Gsp1p-GTP export complex. McGuire AT, et al. Traffic, 2012 Feb. PMID 22008473
    3. Crystal structure of Cex1p reveals the mechanism of tRNA trafficking between nucleus and cytoplasm. Nozawa K, et al. Nucleic Acids Res, 2013 Apr 1. PMID 23396276, Free PMC Article
    4. Cex1 is a component of the COPI intracellular trafficking machinery. Enkler L, et al. Biol Open, 2021 Mar 22. PMID 33753324, Free PMC Article
    5. Cex1p is a novel cytoplasmic component of the Saccharomyces cerevisiae nuclear tRNA export machinery. McGuire AT, et al. EMBO J, 2007 Jan 24. PMID 17203074, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure-based biochemical analyses suggested that Cex1p binds tRNAs on its inner side, using the positively charged HEAT repeat surface and the C-terminal disordered region.
      Title: Crystal structure of Cex1p reveals the mechanism of tRNA trafficking between nucleus and cytoplasm.
    2. Cex1p recruits Rna1p from the cytoplasm to the nuclear pore complex and facilitates Rna1p activation of the GTPase activity of Gsp1p by enabling Rna1p to gain access to Gsp1p-GTP bound to the Los1p-tRNA-Gsp1p-GTP export complex.
      Title: Cex1p facilitates Rna1p-mediated dissociation of the Los1p-tRNA-Gsp1p-GTP export complex.
    3. Cex1p is a component of the nuclear aminoacylation-dependent tRNA export pathway in S. cerevisiae.
      Title: Cex1p is a novel cytoplasmic component of the Saccharomyces cerevisiae nuclear tRNA export machinery.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables tRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA export from nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in tRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA export from nucleus IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Cex1p
    NP_014755.1
    • Component of COPI-mediated trafficking and tRNA nuclear export; enables Rna1p to access and activate Gsp1p-GTP bound to the export receptor tRNA complex during aminoacylation-dependent tRNA export; copurifies with tRNA export receptors; interacts with COPI coat proteins and regulates Golgi-to-ER trafficking; membrane fraction associated; mutations in members of the homologous human SCY1-like (SCYL) family of pseudokinases are linked to peripheral neuropathy, cerebellar atrophy, ataxia and ALS

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      531508..533793
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183531.1 → NP_014755.1  TPA: Cex1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014755.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2H1, Q12453
      UniProtKB/TrEMBL
      A6ZNW0, B3LJF5, N1NWL0
      Conserved Domains (3) summary
      COG5218
      Location:356 → 491
      YCG1; Chromosome condensation complex Condensin, subunit G [Chromatin structure and dynamics / Cell division and chromosome partitioning]
      sd00044
      Location:342 → 371
      HEAT; HEAT repeat [structural motif]
      cl21453
      Location:29 → 257
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12453.1

    Gene LinkOut

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