Krt19 keratin 19 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Krt19provided by MGI
Official Full Name: keratin 19provided by MGI
Primary source: MGI:MGI:96693
See related: Ensembl:ENSMUSG00000020911 AllianceGenome:MGI:96693
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: K19; CK-19; EndoC; Krt1-19; Krt-1.19
Summary: The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Expression: Biased expression in colon adult (RPKM 2054.0), stomach adult (RPKM 1224.1) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 63.42 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (100031636..100036752, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (100140810..100145926, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Group B Streptococcal Adhesin BspC Interacts with Host Cytokeratin 19 To Promote Colonization of the Female Reproductive Tract.
Title: The Group B Streptococcal Adhesin BspC Interacts with Host Cytokeratin 19 To Promote Colonization of the Female Reproductive Tract.
Characterization of Krt19 (CreERT) allele for targeting the nucleus pulposus cells in the postnatal mouse intervertebral disc.
Title: Characterization of Krt19 (CreERT) allele for targeting the nucleus pulposus cells in the postnatal mouse intervertebral disc.
Cytokeratin-19 (CK-19)+ specific deletion of tumor suppressors p53 and Retinoblastoma (Rb) indicated that carcinomas at the injury site originates from cholangiocytes or liver progenitor cells.
Title: Surgical resection and radiofrequency ablation initiate cancer in cytokeratin-19+- liver cells deficient for p53 and Rb.
Demonstrate that K19 plays an important role in the ductular reaction that constitutes the basic regenerative response to chronic liver injury.
Title: Loss of keratin 19 favours the development of cholestatic liver disease through decreased ductular reaction.
Branched desmin-deficient (DKO) myofibers show significantly faster rates of calcium ion (Ca2+) clearance, with milder branching phenotype observed in DKO muscle suggesting that absence of keratin-19 corrects the defect created by absence of desmin alone.
Title: Structural and functional evaluation of branched myofibers lacking intermediate filaments.
the structural response of each genotype is distinct, suggesting multiple mechanisms by which desmin and keratin influence the biomechanical properties of myofibers
Title: Influences of desmin and keratin 19 on passive biomechanical properties of mouse skeletal muscle.
The expression of CK19 and EGFR in lymphatic metastasis of laryngeal carcinoma was higher than in controls.
Title: [Expression of CK19 mRNA and EGFR mRNA in the peripheral blood and its relationship with lymphatic metastasis in laryngeal carcinoma model].
Results suggest that keratin filaments containing K19- and desmin-based intermediate filaments can play independent, complementary, or antagonistic roles in the physiology and morphology of fast-twitch skeletal muscle.
Title: Physiology, structure, and susceptibility to injury of skeletal muscle in mice lacking keratin 19-based and desmin-based intermediate filaments.
a dual mechanism of how PDX-1 negatively regulates Krt19 ductal specific gene expression
Title: The pancreatic and duodenal homeobox protein PDX-1 regulates the ductal specific keratin 19 through the degradation of MEIS1 and DNA binding.
Plastin 1 accumulates in the terminal web and interacts with keratin 19, possibly contributing to anchoring the rootlets to the keratin network.
Title: Plastin 1 binds to keratin and is required for terminal web assembly in the intestinal epithelium.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136193 (e-PCR)
- UniSTS:210188

D8Mit18 (e-PCR), detects polymorphism
- UniSTS:131389

PMC302090P1 (e-PCR)
- UniSTS:272484

Krt1 (e-PCR), detects polymorphism
- UniSTS:143734

Krt1-19 (e-PCR), detects polymorphism
- UniSTS:143740

Krt19 (e-PCR), detects polymorphism
- UniSTS:143741

D11Mit59 (e-PCR), detects polymorphism
- UniSTS:126604

D11Mit59.2 (e-PCR), detects polymorphism
- UniSTS:126605

PMC134648P2 (e-PCR)
- UniSTS:270735

D11Mit59 (e-PCR), detects polymorphism
- UniSTS:141772

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of muscle	IEA Inferred from Electronic Annotation more info
enables structural constituent of muscle	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell differentiation involved in embryonic placenta development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epithelial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to estrogen	IEA Inferred from Electronic Annotation more info
involved_in sarcomere organization	IEA Inferred from Electronic Annotation more info
involved_in sarcomere organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in apicolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	ISO Inferred from Sequence Orthology more info	PubMed
located_in costamere	IEA Inferred from Electronic Annotation more info
located_in costamere	ISO Inferred from Sequence Orthology more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
part_of dystrophin-associated glycoprotein complex	ISO Inferred from Sequence Orthology more info
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in terminal web	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: keratin, type I cytoskeletal 19

Names: cytokeratin 19; keratin complex 1, acidic, gene 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313963.1 → NP_001300892.1 keratin, type I cytoskeletal 19 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate first exon in place of that of variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus compared to isoform 1.

Source sequence(s)

AB472075, AL590873

UniProtKB/TrEMBL

B1AQ78

Related

ENSMUST00000126460.8

Conserved Domains (1) summary

pfam00038
Location:1 → 189

Filament; Intermediate filament protein
NM_008471.3 → NP_032497.1 keratin, type I cytoskeletal 19 isoform 1

See identical proteins and their annotated locations for NP_032497.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AB472075, AL590873

Consensus CDS

CCDS25411.1

UniProtKB/Swiss-Prot

P19001

UniProtKB/TrEMBL

B1AQ78

Related

ENSMUSP00000007317.8, ENSMUST00000007317.8

Conserved Domains (3) summary

cd00890
Location:182 → 307

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

pfam00038
Location:82 → 393

Filament; Intermediate filament protein

cl12013
Location:247 → 402

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature