Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mapk8ip2provided by MGI
Official Full Name: mitogen-activated protein kinase 8 interacting protein 2provided by MGI
Primary source: MGI:MGI:1926555
See related: Ensembl:ENSMUSG00000022619 AllianceGenome:MGI:1926555
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IB2; Jip2; 3230402N03Rik
Summary: Enables kinesin binding activity. Involved in several processes, including behavioral fear response; excitatory postsynaptic potential; and regulation of neurotransmitter receptor activity. Acts upstream of or within JNK cascade. Located in cytoplasm; neuronal cell body; and postsynaptic density. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Used to study autism spectrum disorder. Orthologous to human MAPK8IP2 (mitogen-activated protein kinase 8 interacting protein 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in cerebellum adult (RPKM 62.8), cortex adult (RPKM 45.8) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E3; 15 44.92 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (89338114..89346650)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (89453911..89462447)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data demonstrate that JIP-2 and -2 proteins can influence insulin-stimulated signal transduction mediated by insulin receptor substrate proteins.
Title: Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes.
JIP scaffold proteins are critically required for normal NMDA receptor function.
Title: Requirement of JIP scaffold proteins for NMDA-mediated signal transduction.
there is a signaling module in which IB2 scaffolds a MLK3/MKK/p38delta kinase cascade.
Title: Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase.
JIP2 does not influence the processing of APP, although it is known that both JIP1b and JIP2 equally regulate the JNK signaling cascade
Title: Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW049958 (e-PCR)
- UniSTS:180820

Mapk8ip2 (e-PCR), detects polymorphism
- UniSTS:507054

RH125174 (e-PCR)
- UniSTS:161996

D17S673 (e-PCR)
- UniSTS:11751

AI847694 (e-PCR)
- UniSTS:164589

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables JUN kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables MAP-kinase scaffold activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP-kinase scaffold activity	IEA Inferred from Electronic Annotation more info
enables MAP-kinase scaffold activity	ISO Inferred from Sequence Orthology more info
enables kinesin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within JNK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in behavioral fear response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in nonassociative learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stress-activated MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of AMPA receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of JNK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of NMDA receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of signaling receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in social behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-Jun-amino-terminal kinase-interacting protein 2

Names: IB-2; JIP-2; JNK MAP kinase scaffold protein 2; JNK-interacting protein 2; islet-brain-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021921.3 → NP_068740.3 C-Jun-amino-terminal kinase-interacting protein 2

See identical proteins and their annotated locations for NP_068740.3

Status: VALIDATED

Source sequence(s)

AC137513, AK158968, BC029704, CA317486

Consensus CDS

CCDS27752.1

UniProtKB/Swiss-Prot

Q9CXI4, Q9ERE9

UniProtKB/TrEMBL

Q548W8, Q6PIT2

Related

ENSMUSP00000023291.6, ENSMUST00000023291.6

Conserved Domains (2) summary

cd11942
Location:614 → 668

SH3_JIP2; Src homology 3 domain of JNK-interacting protein 2

cd01212
Location:685 → 830

PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain