U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    TOM22 Tom22p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855592, updated on 28-Oct-2024

    Summary

    Official Symbol
    TOM22
    Official Full Name
    Tom22p
    Primary source
    SGD:S000005075
    Locus tag
    YNL131W
    See related
    AllianceGenome:SGD:S000005075; FungiDB:YNL131W; VEuPathDB:YNL131W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MAS17; MAS22; MOM22
    Summary
    Contributes to protein transmembrane transporter activity. Involved in protein import into mitochondrial matrix and protein insertion into mitochondrial outer membrane. Located in mitochondrial outer membrane. Part of mitochondrial outer membrane translocase complex. Orthologous to human TOMM22 (translocase of outer mitochondrial membrane 22). [provided by Alliance of Genome Resources, Oct 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TOM22 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (378767..379225)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene tRNA-Phe Neighboring gene ribosome biosynthesis protein KRE33 Neighboring gene diacylglycerol cholinephosphotransferase Neighboring gene Dgr1p

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    Tom22p
    NP_014268.1
    • Component of the TOM (Translocase of Outer Membrane) complex; responsible for initial import of mitochondrially directed proteins; mediates interaction between TOM and TIM complexes and acts as receptor for precursor proteins; implicated in mitochondrial accumulation of amyloid beta peptides via direct interaction with amyloid beta peptide residues 25-42 followed by transfer to Tom40p and transport through the TOM channel

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      378767..379225
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182969.1NP_014268.1  TPA: Tom22p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014268.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W151, P49334, Q36757
      UniProtKB/TrEMBL
      A6ZRV2, B3LNY8, C7GKB5, C8ZG99, G2WLX5, N1NXV1
      Conserved Domains (1) summary
      cl11522
      Location:1152
      Tom22; Mitochondrial import receptor subunit Tom22