Acsl1 acyl-CoA synthetase long-chain family member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acsl1provided by MGI
Official Full Name: acyl-CoA synthetase long-chain family member 1provided by MGI
Primary source: MGI:MGI:102797
See related: Ensembl:ENSMUSG00000018796 AllianceGenome:MGI:102797
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Acs; Acas; FACS; Acas1; Facl2; LACS1; LACS 1
Summary: The protein encoded by this gene belongs to a family of acyl coenzyme A synthetase proteins, which convert long chain fatty acids to acyl CoA products via an ATP-dependent pathway. This enzyme is enriched in heart, liver and adipose tissue, where it functions in lipid synthesis and mitochondrial and peroxisomal beta-oxidation. In addition, it is expressed in monocytes and macrophages where it appears to have a functionally distinct role in mediating inflammatory and innate immune responses. A pseudogene of this gene is found on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression: Biased expression in liver E18 (RPKM 94.6), subcutaneous fat pad adult (RPKM 79.5) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B1.1; 8 26.36 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (46924214..46989088)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (46471037..46536051)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

shRNA-mediated down-regulation of Acsl1 reverses skeletal muscle insulin resistance in obese C57BL6/J mice.
Title: shRNA-mediated down-regulation of Acsl1 reverses skeletal muscle insulin resistance in obese C57BL6/J mice.
Acsl1 is essential for skin barrier function through the activation of linoleic acid and biosynthesis of omega-O-acylceramide in mice.
Title: Acsl1 is essential for skin barrier function through the activation of linoleic acid and biosynthesis of ω-O-acylceramide in mice.
Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1.
Title: Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1.
PRMT7-Dependent Transcriptional Activation of Hmgb2 Aggravates Severe Acute Pancreatitis by Promoting Acsl1-Induced Ferroptosis.
Title: PRMT7-Dependent Transcriptional Activation of Hmgb2 Aggravates Severe Acute Pancreatitis by Promoting Acsl1-Induced Ferroptosis.
ACSL1: A preliminary study that provides a new target for the treatment of renal fibrosis could bring new insights in diabetic kidney disease.
Title: ACSL1: A preliminary study that provides a new target for the treatment of renal fibrosis could bring new insights in diabetic kidney disease.
Fatty acids and inflammatory stimuli induce expression of long-chain acyl-CoA synthetase 1 to promote lipid remodeling in diabetic kidney disease.
Title: Fatty acids and inflammatory stimuli induce expression of long-chain acyl-CoA synthetase 1 to promote lipid remodeling in diabetic kidney disease.
RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4.
Title: RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4.
Loss of long-chain acyl-CoA synthetase 1 promotes hepatocyte death in alcohol-induced steatohepatitis.
Title: Loss of long-chain acyl-CoA synthetase 1 promotes hepatocyte death in alcohol-induced steatohepatitis.
Transcriptional regulation of Acsl1 by CHREBP and NF-kappa B in macrophages during hyperglycemia and inflammation.
Title: Transcriptional regulation of Acsl1 by CHREBP and NF-kappa B in macrophages during hyperglycemia and inflammation.
Targeting ACSL1 promotes cardiomyocyte proliferation and cardiac regeneration.
Title: Targeting ACSL1 promotes cardiomyocyte proliferation and cardiac regeneration.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Acsl1 (e-PCR), detects polymorphism
- UniSTS:506707

Acsl1 (e-PCR), detects polymorphism
- UniSTS:499074

Acsl1 (e-PCR), detects polymorphism
- UniSTS:502702

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables arachidonate-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arachidonate-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables arachidonate-CoA ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables long-chain fatty acid-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid-CoA ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables oleoyl-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables oleoyl-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables phytanate-CoA ligase activity	ISO Inferred from Sequence Orthology more info
enables phytanate-CoA ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables pristanate-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein serine/threonine kinase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within adiponectin-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in lipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid import into cell	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid import into cell	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in long-chain fatty-acyl-CoA biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty-acyl-CoA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty-acyl-CoA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of long-chain fatty acid import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of long-chain fatty acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient	IEA Inferred from Electronic Annotation more info
involved_in response to oleic acid	IEA Inferred from Electronic Annotation more info
involved_in response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
involved_in triglyceride biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in triglyceride biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in very long-chain fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in very long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in very long-chain fatty acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in xenobiotic catabolic process	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
located_in peroxisomal membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: long-chain-fatty-acid--CoA ligase 1

Names: acetate-CoA ligase; acetyl-CoA synthetase; acetyl-Coenzyme A synthetase 1 (ADP forming); arachidonate--CoA ligase; fatty acid Coenzyme A ligase, long chain 2; long-chain acyl-CoA synthetase 1; phytanate--CoA ligase

NP_001289092.1

EC 6.2.1.15

EC 6.2.1.24

EC 6.2.1.3

NP_001411721.1

EC 6.2.1.15

EC 6.2.1.24

EC 6.2.1.3

NP_001411722.1

EC 6.2.1.15

EC 6.2.1.24

EC 6.2.1.3

NP_001411723.1

EC 6.2.1.15

EC 6.2.1.24

EC 6.2.1.3

NP_032007.2

EC 6.2.1.15

EC 6.2.1.24

EC 6.2.1.3

XP_006509325.2

EC 6.2.1.15

EC 6.2.1.24

EC 6.2.1.3

XP_006509328.1

EC 6.2.1.15

EC 6.2.1.24

EC 6.2.1.3

XP_006509329.1

EC 6.2.1.15

EC 6.2.1.24

EC 6.2.1.3

XP_017168052.1

EC 6.2.1.15

EC 6.2.1.24

EC 6.2.1.3

XP_030099145.1

EC 6.2.1.15

EC 6.2.1.24

EC 6.2.1.3

XP_036009645.1

EC 6.2.1.15

EC 6.2.1.24

EC 6.2.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001302163.2 → NP_001289092.1 long-chain-fatty-acid--CoA ligase 1 isoform 1

See identical proteins and their annotated locations for NP_001289092.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.

Source sequence(s)

AC119267, AC138367

Consensus CDS

CCDS22291.1

UniProtKB/Swiss-Prot

P41216, Q6GTG6, Q9DBK5

Related

ENSMUSP00000106001.2, ENSMUST00000110372.9

Conserved Domains (1) summary

cd05927
Location:117 → 695

LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
NM_001424792.1 → NP_001411721.1 long-chain-fatty-acid--CoA ligase 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC119267, AC138367

UniProtKB/Swiss-Prot

P41216, Q6GTG6, Q9DBK5
NM_001424793.1 → NP_001411722.1 long-chain-fatty-acid--CoA ligase 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC119267, AC138367
NM_001424794.1 → NP_001411723.1 long-chain-fatty-acid--CoA ligase 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC119267, AC138367
NM_007981.5 → NP_032007.2 long-chain-fatty-acid--CoA ligase 1 isoform 1

See identical proteins and their annotated locations for NP_032007.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) has a distinct 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).

Source sequence(s)

AC119267, AC138367

Consensus CDS

CCDS22291.1

UniProtKB/Swiss-Prot

P41216, Q6GTG6, Q9DBK5

Related

ENSMUSP00000034046.6, ENSMUST00000034046.13

Conserved Domains (1) summary

cd05927
Location:117 → 695

LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

46924214..46989088

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017312563.3 → XP_017168052.1 long-chain-fatty-acid--CoA ligase 1 isoform X1

UniProtKB/Swiss-Prot

P41216, Q6GTG6, Q9DBK5

Conserved Domains (1) summary

cd05927
Location:117 → 695

LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
XM_006509266.4 → XP_006509329.1 long-chain-fatty-acid--CoA ligase 1 isoform X1

See identical proteins and their annotated locations for XP_006509329.1

UniProtKB/Swiss-Prot

P41216, Q6GTG6, Q9DBK5

Conserved Domains (1) summary

cd05927
Location:117 → 695

LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
XM_006509265.4 → XP_006509328.1 long-chain-fatty-acid--CoA ligase 1 isoform X1

See identical proteins and their annotated locations for XP_006509328.1

UniProtKB/Swiss-Prot

P41216, Q6GTG6, Q9DBK5

Conserved Domains (1) summary

cd05927
Location:117 → 695

LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
XM_030243285.2 → XP_030099145.1 long-chain-fatty-acid--CoA ligase 1 isoform X3

UniProtKB/TrEMBL

D3Z041

Related

ENSMUSP00000106000.2, ENSMUST00000110371.8

Conserved Domains (1) summary

cd05927
Location:117 → 695

LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
XM_006509262.4 → XP_006509325.2 long-chain-fatty-acid--CoA ligase 1 isoform X1

See identical proteins and their annotated locations for XP_006509325.2

UniProtKB/Swiss-Prot

P41216, Q6GTG6, Q9DBK5

Conserved Domains (1) summary

cd05927
Location:117 → 695

LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
XM_036153752.1 → XP_036009645.1 long-chain-fatty-acid--CoA ligase 1 isoform X2

Conserved Domains (1) summary

cl17068
Location:1 → 370

AFD_class_I; Adenylate forming domain, Class I superfamily