Gstm7 glutathione S-transferase, mu 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gstm7provided by MGI
Official Full Name: glutathione S-transferase, mu 7provided by MGI
Primary source: MGI:MGI:1915562
See related: Ensembl:ENSMUSG00000004035 AllianceGenome:MGI:1915562
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cd203c; 0610005A07Rik
Summary: Predicted to enable several functions, including anion binding activity; glutathione peroxidase activity; and glutathione transferase activity. Predicted to be involved in several processes, including cellular detoxification of nitrogen compound; long-chain fatty acid metabolic process; and regulation of release of sequestered calcium ion into cytosol. Predicted to be located in cytosol; intercellular bridge; and sarcoplasmic reticulum. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; genitourinary system; and sensory organ. Orthologous to human GSTM2 (glutathione S-transferase mu 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in genital fat pad adult (RPKM 289.7), liver adult (RPKM 39.7) and 8 other tissues See more
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Genomic context

Location:: 3 F2.3; 3 46.83 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (107833650..107839193, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (107926334..107931877, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In this Perspective, I discuss results presented in this month's issue of Aging Cell that address whether the types of DNA damage repaired by the base excision repair pathway cause aging in yeast.
Title: Is DNA cut out for a long life?

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gstm7 (e-PCR), detects polymorphism
- UniSTS:527379

RH127684 (e-PCR)
- UniSTS:210994

AI894236 (e-PCR)
- UniSTS:178917

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables fatty acid binding	IEA Inferred from Electronic Annotation more info
enables fatty acid binding	ISO Inferred from Sequence Orthology more info
enables glutathione binding	IEA Inferred from Electronic Annotation more info
enables glutathione binding	ISO Inferred from Sequence Orthology more info
enables glutathione peroxidase activity	IEA Inferred from Electronic Annotation more info
enables glutathione peroxidase activity	ISO Inferred from Sequence Orthology more info
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info
enables glutathione transferase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular detoxification of nitrogen compound	IEA Inferred from Electronic Annotation more info
involved_in cellular detoxification of nitrogen compound	ISO Inferred from Sequence Orthology more info
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cellular response to caffeine	IEA Inferred from Electronic Annotation more info
involved_in cellular response to caffeine	ISO Inferred from Sequence Orthology more info
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glutathione metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hepoxilin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in hepoxilin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in linoleic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in linoleic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ryanodine-sensitive calcium-release channel activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ryanodine-sensitive calcium-release channel activity	ISO Inferred from Sequence Orthology more info
involved_in nitrobenzene metabolic process	IEA Inferred from Electronic Annotation more info
involved_in nitrobenzene metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ryanodine-sensitive calcium-release channel activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ryanodine-sensitive calcium-release channel activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic catabolic process	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutathione S-transferase Mu 7

Names: GST class-mu 7

NP_001343280.1

EC 2.5.1.18

NP_080948.2

EC 2.5.1.18

XP_006502034.1

EC 2.5.1.18

XP_006502036.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356351.2 → NP_001343280.1 glutathione S-transferase Mu 7 isoform 2

Status: VALIDATED

Source sequence(s)

AC079042

Consensus CDS

CCDS89676.1

UniProtKB/TrEMBL

D3YVP5

Related

ENSMUSP00000102299.2, ENSMUST00000106688.8

Conserved Domains (2) summary

cd03209
Location:88 → 208

GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases

cd03075
Location:9 → 80

GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
NM_001429089.1 → NP_001416018.1 glutathione S-transferase Mu 7 isoform 3

Status: VALIDATED

Source sequence(s)

AC079042
NM_001429090.1 → NP_001416019.1 glutathione S-transferase Mu 7 isoform 4

Status: VALIDATED

Source sequence(s)

AC079042
NM_026672.4 → NP_080948.2 glutathione S-transferase Mu 7 isoform 1

See identical proteins and their annotated locations for NP_080948.2

Status: VALIDATED

Source sequence(s)

AC079042

Consensus CDS

CCDS38595.1

UniProtKB/Swiss-Prot

Q3TRV7, Q3V4E2, Q80W21

UniProtKB/TrEMBL

D3YVP6

Related

ENSMUSP00000004137.4, ENSMUST00000004137.11

Conserved Domains (2) summary

cd03209
Location:92 → 212

GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases

cd03075
Location:3 → 84

GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

107833650..107839193 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501971.4 → XP_006502034.1 glutathione S-transferase Mu 7 isoform X1

Conserved Domains (2) summary

cd03209
Location:99 → 219

GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases

cd03075
Location:20 → 91

GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
XM_006501973.4 → XP_006502036.1 glutathione S-transferase Mu 7 isoform X2

Conserved Domains (2) summary

cd03209
Location:82 → 202

GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases

cd03075
Location:3 → 74

GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...