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    Slc16a4 solute carrier family 16 (monocarboxylic acid transporters), member 4 [ Mus musculus (house mouse) ]

    Gene ID: 229699, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Slc16a4provided by MGI
    Official Full Name
    solute carrier family 16 (monocarboxylic acid transporters), member 4provided by MGI
    Primary source
    MGI:MGI:2385183
    See related
    Ensembl:ENSMUSG00000027896 AllianceGenome:MGI:2385183
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MCT 5
    Summary
    Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in carboxylic acid transmembrane transport. Predicted to be active in plasma membrane. Is expressed in choroid plexus; cranium; otic capsule; and thoracic segment skeleton. Orthologous to human SLC16A4 (solute carrier family 16 member 4). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in kidney adult (RPKM 15.5), limb E14.5 (RPKM 2.4) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc16a4 in Genome Data Viewer
    Location:
    3 F2.3; 3 46.81 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (107198543..107219437)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (107291230..107312115)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A630076J17 gene Neighboring gene STARR-positive B cell enhancer ABC_E6103 Neighboring gene prokineticin 1 Neighboring gene STARR-positive B cell enhancer mm9_chr3:107081789-107082089 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 Neighboring gene RNA binding motif protein 15 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:107136515-107136698 Neighboring gene STARR-seq mESC enhancer starr_08664 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide pseudogene Neighboring gene predicted gene, 35700

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deletion of the amino acid transporter Slc6a14 suppresses tumour growth in spontaneous mouse models of breast cancer. Babu E, et al. Biochem J, 2015 Jul 1. PMID 26173258
    2. Enhanced expression of three monocarboxylate transporter isoforms in the brain of obese mice. Pierre K, et al. J Physiol, 2007 Sep 1. PMID 17599960, Free PMC Article
    3. Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation. Zhang Y, et al. Cell Rep, 2024 May 28. PMID 38733581
    4. Distribution of monocarboxylate transporters in the peripheral nervous system suggests putative roles in lactate shuttling and myelination. Domènech-Estévez E, et al. J Neurosci, 2015 Mar 11. PMID 25762662, Free PMC Article
    5. Foxp1 suppresses cortical angiogenesis and attenuates HIF-1alpha signaling to promote neural progenitor cell maintenance. Buth JE, et al. EMBO Rep, 2024 May. PMID 38600346, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation.
      Title: Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation.
    2. This study showed that mouse MCT1, MCT2, and MCT4 are expressed in the PNS. While DRG neurons express MCT1, myelinating Schwann cells.
      Title: Distribution of monocarboxylate transporters in the peripheral nervous system suggests putative roles in lactate shuttling and myelination.
    3. Expression of cerebral MCT isoforms can be modulated by alterations of peripheral metabolism, suggesting that the adult brain is sensitive and adapts to new metabolic states.
      Title: Enhanced expression of three monocarboxylate transporter isoforms in the brain of obese mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC37305

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables monocarboxylic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carboxylic acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    monocarboxylate transporter 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310705.2 → NP_001297634.1  monocarboxylate transporter 5 isoform 2

      See identical proteins and their annotated locations for NP_001297634.1

      Status: VALIDATED

      Source sequence(s)
      AC132405
      Consensus CDS
      CCDS79997.1
      UniProtKB/Swiss-Prot
      Q8R0M8
      Related
      ENSMUSP00000102334.2, ENSMUST00000106723.2
      Conserved Domains (2) summary
      cd06174
      Location:24 → 198
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:27 → 447
      MFS_1; Major Facilitator Superfamily

    2. NM_146136.3 → NP_666248.1  monocarboxylate transporter 5 isoform 1

      See identical proteins and their annotated locations for NP_666248.1

      Status: VALIDATED

      Source sequence(s)
      AC132405
      Consensus CDS
      CCDS17736.1
      UniProtKB/Swiss-Prot
      Q8BLA5, Q8BWE3, Q8R0M8, Q8R157
      Related
      ENSMUSP00000029502.8, ENSMUST00000029502.14
      Conserved Domains (2) summary
      cd06174
      Location:24 → 482
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00892
      Location:7 → 479
      2A0113; monocarboxylate transporter 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      107198543..107219437
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163075.1 → XP_036018968.1  monocarboxylate transporter 5 isoform X1

      Conserved Domains (1) summary
      cl28910
      Location:20 → 461
      MFS; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R0M8.1 GenPept UniProtKB/Swiss-Prot:Q8R0M8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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