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    Fmnl3 formin-like 3 [ Mus musculus (house mouse) ]

    Gene ID: 22379, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Fmnl3provided by MGI
    Official Full Name
    formin-like 3provided by MGI
    Primary source
    MGI:MGI:109569
    See related
    Ensembl:ENSMUSG00000023008 AllianceGenome:MGI:109569
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wbp3; FBP11; mKIAA2014; 2700073B04Rik
    Summary
    Enables GTPase activating protein binding activity. Predicted to be involved in several processes, including cortical actin cytoskeleton organization; filopodium assembly; and regulation of cell shape. Predicted to be located in Golgi apparatus and plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and retina. Orthologous to human FMNL3 (formin like 3). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 22.2), ovary adult (RPKM 18.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fmnl3 in Genome Data Viewer
    Location:
    15 F1; 15 56.13 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99215091..99268375, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99317210..99370521, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700120C14 gene Neighboring gene STARR-positive B cell enhancer ABC_E7417 Neighboring gene predicted gene, 25999 Neighboring gene family with sequence similarity 186, member B Neighboring gene pre-mRNA processing factor 40B Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:99163430-99163646 Neighboring gene STARR-seq mESC enhancer starr_39705 Neighboring gene STARR-positive B cell enhancer ABC_E9923 Neighboring gene STARR-positive B cell enhancer ABC_E3156 Neighboring gene predicted gene, 22951 Neighboring gene transmembrane BAX inhibitor motif containing 6 Neighboring gene STARR-positive B cell enhancer ABC_E761 Neighboring gene VISTA enhancer mm1635 Neighboring gene NCK-associated protein 5-like Neighboring gene NCK-associated protein 5-like, opposite strand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The C terminus of formin FMNL3 accelerates actin polymerization and contains a WH2 domain-like sequence that binds both monomers and filament barbed ends. Heimsath EG Jr, et al. J Biol Chem, 2012 Jan 27. PMID 22094460, Free PMC Article
    2. FMNL3 FH2-actin structure gives insight into formin-mediated actin nucleation and elongation. Thompson ME, et al. Nat Struct Mol Biol, 2013 Jan. PMID 23222643, Free PMC Article
    3. FMNL formins boost lamellipodial force generation. Kage F, et al. Nat Commun, 2017 Mar 22. PMID 28327544, Free PMC Article
    4. The formin FMNL3 assembles plasma membrane protrusions that participate in cell-cell adhesion. Gauvin TJ, et al. Mol Biol Cell, 2015 Feb 1. PMID 25428984, Free PMC Article
    5. FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42. Kage F, et al. Sci Rep, 2017 Aug 29. PMID 28852060, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our data thus link FMNL2/3 formins to actin assembly-dependent functions of Cdc42 in anterograde transport through the Golgi apparatus.
      Title: FMNL2 and -3 regulate Golgi architecture and anterograde transport downstream of Cdc42.
    2. force generation in lamellipodia strongly depends on FMNL formin activity.
      Title: FMNL formins boost lamellipodial force generation.
    3. FMNL3 functions in assembly of actin-based protrusions that are specialized for cell-cell adhesion.
      Title: The formin FMNL3 assembles plasma membrane protrusions that participate in cell-cell adhesion.
    4. 3.4-A structure of FMNL3 FH2 dimer in complex with tetramethylrhodamine-actin uncovers details of formin-regulated actin elongation; structure provides details for FH2-mediated filament elongation by processive capping and supports a model in which C-terminal non-FH2 residues of FMNL3 are required to stabilize the filament nucleus
      Title: FMNL3 FH2-actin structure gives insight into formin-mediated actin nucleation and elongation.
    5. The C terminus of formin FMNL3 accelerates actin polymerization and contains a WH2 domain-like sequence that binds both monomers and filament barbed ends.
      Title: The C terminus of formin FMNL3 accelerates actin polymerization and contains a WH2 domain-like sequence that binds both monomers and filament barbed ends.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activating protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cortical actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in filopodium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell shape ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    formin-like protein 3
    Names
    WW domain binding protein 3
    formin-like 3 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310622.1 → NP_001297551.1  formin-like protein 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks the penultimate exon compared to variant 1, which results in a frame-shift and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC118646, AK163361, AU042388, BC131961
      Consensus CDS
      CCDS79409.1
      UniProtKB/TrEMBL
      D3Z7A7
      Related
      ENSMUSP00000113094.2, ENSMUST00000120633.2
      Conserved Domains (3) summary
      pfam02181
      Location:561 → 926
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:281 → 472
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:26 → 278
      Drf_GBD; Diaphanous GTPase-binding Domain

    2. NM_001310623.1 → NP_001297552.1  formin-like protein 3 isoform 3

      See identical proteins and their annotated locations for NP_001297552.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame coding exon in the mid region and the penultimate exon compared to variant 1. The resulting isoform (3) is shorter missing an internal protein segment and with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC118646, AU042388, BC131961
      Consensus CDS
      CCDS79408.1
      UniProtKB/Swiss-Prot
      Q6ZPF4
      Related
      ENSMUSP00000079984.8, ENSMUST00000081224.14
      Conserved Domains (3) summary
      pfam02181
      Location:510 → 875
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:230 → 421
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:26 → 227
      Drf_GBD; Diaphanous GTPase-binding Domain

    3. NM_011711.2 → NP_035841.1  formin-like protein 3 isoform 1

      See identical proteins and their annotated locations for NP_035841.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC118646, AU042388, BC131961
      Consensus CDS
      CCDS27819.1
      UniProtKB/Swiss-Prot
      Q3TCF9, Q3U2E4, Q6ZPF4
      Related
      ENSMUSP00000085566.7, ENSMUST00000088233.13
      Conserved Domains (3) summary
      pfam02181
      Location:561 → 926
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:281 → 472
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:26 → 278
      Drf_GBD; Diaphanous GTPase-binding Domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      99215091..99268375 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520844.5 → XP_006520907.1  formin-like protein 3 isoform X1

      Conserved Domains (3) summary
      pfam02181
      Location:510 → 875
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:230 → 421
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:26 → 227
      Drf_GBD; Diaphanous GTPase-binding Domain

    2. XM_030248512.2 → XP_030104372.1  formin-like protein 3 isoform X2

      Conserved Domains (3) summary
      pfam02181
      Location:327 → 692
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:47 → 238
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:1 → 44
      Drf_GBD; Diaphanous GTPase-binding Domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZPF4.2 GenPept UniProtKB/Swiss-Prot:Q6ZPF4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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