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    Nkain2 Na+/K+ transporting ATPase interacting 2 [ Mus musculus (house mouse) ]

    Gene ID: 432450, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nkain2provided by MGI
    Official Full Name
    Na+/K+ transporting ATPase interacting 2provided by MGI
    Primary source
    MGI:MGI:1923447
    See related
    Ensembl:ENSMUSG00000069670 AllianceGenome:MGI:1923447
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tcba1; 6330571D19Rik
    Summary
    Predicted to be involved in regulation of sodium ion transport. Located in plasma membrane. Is expressed in cerebellum. Orthologous to human NKAIN2 (sodium/potassium transporting ATPase interacting 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 5.4), frontal lobe adult (RPKM 4.4) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nkain2 in Genome Data Viewer
    Location:
    10 A4; 10 17.56 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (31565314..32773170, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (31689310..32897174, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26217 Neighboring gene STARR-seq mESC enhancer starr_26218 Neighboring gene STARR-seq mESC enhancer starr_26219 Neighboring gene ring finger protein 217 Neighboring gene STARR-seq mESC enhancer starr_26220 Neighboring gene STARR-seq mESC enhancer starr_26221 Neighboring gene high mobility group box 2 pseudogene Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_26222 Neighboring gene STARR-seq mESC enhancer starr_26223 Neighboring gene STARR-seq mESC enhancer starr_26224 Neighboring gene STARR-seq mESC enhancer starr_26225 Neighboring gene Braf transforming gene pseudogene Neighboring gene STARR-seq mESC enhancer starr_26226 Neighboring gene STARR-seq mESC enhancer starr_26227 Neighboring gene Smad nuclear interacting protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26228 Neighboring gene STARR-seq mESC enhancer starr_26229 Neighboring gene STARR-seq mESC enhancer starr_26230 Neighboring gene STARR-seq mESC enhancer starr_26231 Neighboring gene STARR-seq mESC enhancer starr_26233 Neighboring gene STARR-seq mESC enhancer starr_26234 Neighboring gene STARR-seq mESC enhancer starr_26235 Neighboring gene STARR-seq mESC enhancer starr_26236 Neighboring gene STARR-seq mESC enhancer starr_26237 Neighboring gene STARR-seq mESC enhancer starr_26238 Neighboring gene STARR-seq mESC enhancer starr_26239 Neighboring gene RIKEN cDNA D830005E20 gene Neighboring gene STARR-seq mESC enhancer starr_26243 Neighboring gene triadin Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of a t(2;6) balanced translocation that is associated with a complex phenotype and leads to truncation of the TCBA1 gene. Bocciardi R, et al. Hum Mutat, 2005 Nov. PMID 16145689
    2. Disruption of TCBA1 associated with a de novo t(1;6)(q32.2;q22.3) presenting in a child with developmental delay and recurrent infections. Yue Y, et al. J Med Genet, 2006 Feb. PMID 15908570, Free PMC Article
    3. Motor phenotypes and molecular networks associated with germline deficiency of Ciz1. Xiao J, et al. Exp Neurol, 2016 Sep. PMID 27163549, Free PMC Article
    4. A novel family of transmembrane proteins interacting with beta subunits of the Na,K-ATPase. Gorokhova S, et al. Hum Mol Genet, 2007 Oct 15. PMID 17606467
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in regulation of sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2
    Names
    Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 2
    T-cell lymphoma breakpoint associated target 1
    T-cell lymphoma breakpoint-associated target protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013411.2 → NP_001013429.2  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2 long isoform

      See identical proteins and their annotated locations for NP_001013429.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the long isoform.
      Source sequence(s)
      AC126430, AY940478, BY247478, EF058049
      Consensus CDS
      CCDS78805.1
      UniProtKB/Swiss-Prot
      A6MHP5, A6MHP6, A6MHP7, B2RUC0, Q4PNJ2, Q4PNJ3, Q5BLW8
      UniProtKB/TrEMBL
      A0A1W2P6G7
      Related
      ENSMUSP00000140463.2, ENSMUST00000191234.7
      Conserved Domains (1) summary
      pfam05640
      Location:10 → 207
      NKAIN; Na,K-Atpase Interacting protein

    2. NM_001025286.2 → NP_001020457.2  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2 short isoform

      See identical proteins and their annotated locations for NP_001020457.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different segment for its 3' coding region and 3' UTR, compared to variant 1. The resulting protein (known as the short isoform) has a shorter and distinct C-terminus when it is compared to the long isoform.
      Source sequence(s)
      AC133511, BC141063, BY247478
      Consensus CDS
      CCDS87984.1
      UniProtKB/Swiss-Prot
      Q4PNJ2
      Related
      ENSMUSP00000151959.2, ENSMUST00000219125.2
      Conserved Domains (1) summary
      pfam05640
      Location:10 → 159
      NKAIN; Na,K-Atpase Interacting protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      31565314..32773170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155888.1 → XP_036011781.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A1W2P6G7
      Conserved Domains (1) summary
      pfam05640
      Location:10 → 180
      NKAIN; Na,K-Atpase Interacting protein

    RNA

    1. XR_004936218.1 RNA Sequence

    2. XR_003948726.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4PNJ2.2 GenPept UniProtKB/Swiss-Prot:Q4PNJ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials