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    Slc2a6 solute carrier family 2 (facilitated glucose transporter), member 6 [ Mus musculus (house mouse) ]

    Gene ID: 227659, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Slc2a6provided by MGI
    Official Full Name
    solute carrier family 2 (facilitated glucose transporter), member 6provided by MGI
    Primary source
    MGI:MGI:2443286
    See related
    Ensembl:ENSMUSG00000036067 AllianceGenome:MGI:2443286
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Glut6; Glut9; GLUT-6; A330096C23; F630103L12Rik
    Summary
    Predicted to enable transmembrane transporter activity. Involved in regulation of glycolytic process. Predicted to be located in lysosomal membrane. Predicted to be active in membrane. Orthologous to human SLC2A6 (solute carrier family 2 member 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 12.1), spleen adult (RPKM 11.0) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc2a6 in Genome Data Viewer
    Location:
    2 A3; 2 19.18 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26911375..26918011, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (27021363..27028000, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 36649 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 13 Neighboring gene STARR-positive B cell enhancer ABC_E7799 Neighboring gene calcium channel flower domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E5901 Neighboring gene STARR-positive B cell enhancer ABC_E7800 Neighboring gene STARR-seq mESC enhancer starr_03998 Neighboring gene ribosomal protein L6 pseudogene Neighboring gene predicted gene 13398

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Knockout of glucose transporter GLUT6 has minimal effects on whole body metabolic physiology in mice. Byrne FL, et al. Am J Physiol Endocrinol Metab, 2018 Aug 1. PMID 29664675
    2. Investigating the Expression and Function of the Glucose Transporter GLUT6 in Obesity. Chen SY, et al. Int J Mol Sci, 2022 Aug 29. PMID 36077188, Free PMC Article
    3. Characterization of Glucose Transporter 6 in Lipopolysaccharide-Induced Bone Marrow-Derived Macrophage Function. Caruana BT, et al. J Immunol, 2019 Mar 15. PMID 30700586
    4. GLUT6 is a lysosomal transporter that is regulated by inflammatory stimuli and modulates glycolysis in macrophages. Maedera S, et al. FEBS Lett, 2019 Jan. PMID 30431159
    5. No development of hypertension in the hyperuricemic liver-Glut9 knockout mouse. Preitner F, et al. Kidney Int, 2015 May. PMID 25565311

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Investigating the Expression and Function of the Glucose Transporter GLUT6 in Obesity.
      Title: Investigating the Expression and Function of the Glucose Transporter GLUT6 in Obesity.
    2. Study provides evidence that GLUT6 is a lysosomal transporter that is regulated by inflammatory stimuli and modulates inflammatory responses by affecting the metabolic shift in macrophages.
      Title: GLUT6 is a lysosomal transporter that is regulated by inflammatory stimuli and modulates glycolysis in macrophages.
    3. these data show that GLUT6 is not a major regulator of whole body metabolic physiology
      Title: Knockout of glucose transporter GLUT6 has minimal effects on whole body metabolic physiology in mice.
    4. In liver-specific Glut9 knockout mice, inosine-induced hyperuricemia was not associated with hypertension despite partial renal deficiency.
      Title: No development of hypertension in the hyperuricemic liver-Glut9 knockout mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5)  1 citation
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables D-glucose transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in D-glucose transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 2, facilitated glucose transporter member 6
    Names
    glucose transporter type 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177627.1 → NP_001171098.1  solute carrier family 2, facilitated glucose transporter member 6 isoform 2

      See identical proteins and their annotated locations for NP_001171098.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region compared to variant 1. The resulting isoform (2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      BC058210, BC141168, BY202464
      Consensus CDS
      CCDS50544.1
      UniProtKB/TrEMBL
      A2AR26
      Related
      ENSMUSP00000099954.5, ENSMUST00000102890.11
      Conserved Domains (2) summary
      cd06174
      Location:41 → 415
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:40 → 434
      Sugar_tr; Sugar (and other) transporter

    2. NM_172659.2 → NP_766247.2  solute carrier family 2, facilitated glucose transporter member 6 isoform 1

      See identical proteins and their annotated locations for NP_766247.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK150104, BY202464
      Consensus CDS
      CCDS15822.1
      UniProtKB/Swiss-Prot
      A2AR26, Q3TLU5, Q3UDF0, Q8BTN2
      Related
      ENSMUSP00000049103.6, ENSMUST00000045702.6
      Conserved Domains (1) summary
      cl28910
      Location:38 → 483
      MFS; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      26911375..26918011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497917.5 → XP_006497980.1  solute carrier family 2, facilitated glucose transporter member 6 isoform X1

      Conserved Domains (1) summary
      cl28910
      Location:1 → 385
      MFS; Major Facilitator Superfamily

    RNA

    1. XR_374081.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UDF0.1 GenPept UniProtKB/Swiss-Prot:Q3UDF0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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