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    Mycl v-myc avian myelocytomatosis viral oncogene lung carcinoma derived [ Mus musculus (house mouse) ]

    Gene ID: 16918, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Myclprovided by MGI
    Official Full Name
    v-myc avian myelocytomatosis viral oncogene lung carcinoma derivedprovided by MGI
    Primary source
    MGI:MGI:96799
    See related
    Ensembl:ENSMUSG00000028654 AllianceGenome:MGI:96799
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    L-myc; Lmyc1; Mycl1; Lmyc-1; bHLHe38
    Summary
    This gene encodes a basic helix-loop-helix leucine zipper (bHLHZip) protein that heterodimerizes with another bHLHZip protein to drive transcription of targets important for proliferation, apoptosis and differentiation. Mice lacking this gene product show marked decrease in T-cell priming during bacterial and viral infections. In humans, this gene was found to be amplified in small-cell lung cancers. Alternate splicing of this gene results in multiple variants. [provided by RefSeq, Dec 2014]
    Expression
    Broad expression in whole brain E14.5 (RPKM 22.3), CNS E11.5 (RPKM 19.2) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mycl in Genome Data Viewer
    Location:
    4 D2.2; 4 57.36 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (122889414..122896278)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (122995588..123002490)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3510 Neighboring gene CDC28 protein kinase regulatory subunit 2 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr4:122616319-122616620 Neighboring gene MFSD2 lysolipid transporter A, lysophospholipid Neighboring gene STARR-positive B cell enhancer ABC_E7983 Neighboring gene predicted gene, 54255 Neighboring gene STARR-positive B cell enhancer ABC_E11253 Neighboring gene STARR-positive B cell enhancer ABC_E2710 Neighboring gene STARR-positive B cell enhancer ABC_E3511 Neighboring gene tRNA isopentenyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E4662 Neighboring gene STARR-positive B cell enhancer ABC_E4663 Neighboring gene predicted gene 12923 Neighboring gene predicted gene, 46868

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An Eco RI restriction length polymorphism at the murine L-myc locus. Dolcetti R, et al. Nucleic Acids Res, 1988 Dec 23. PMID 2905449, Free PMC Article
    2. Differential expression of myc family genes during murine development. Zimmerman KA, et al. Nature, 1986 Feb 27-Mar 5. PMID 2419762
    3. The MYCL and MXD1 transcription factors regulate the fitness of murine dendritic cells. Anderson DA 3rd, et al. Proc Natl Acad Sci U S A, 2020 Mar 3. PMID 32071205, Free PMC Article
    4. Long-depth imaging of specific gene expressions in whole-mount mouse embryos with single-photon excitation confocal fluorescence microscopy and FISH. Palmes-Saloma C, et al. J Struct Biol, 2000 Jul. PMID 10945970
    5. Structure and expression of the murine L-myc gene. Legouy E, et al. EMBO J, 1987 Nov. PMID 2828024, Free PMC Article

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The MYCL and MXD1 transcription factors regulate the fitness of murine dendritic cells.
      Title: The MYCL and MXD1 transcription factors regulate the fitness of murine dendritic cells.
    2. Deletion of Mycl in two genetically engineered models of SCLC resulted in strong suppression of SCLC
      Title: Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer.
    3. Mycl1 is expressed exclusively by dendritic cells; unlike c-Myc, the L-Myc transcription factor is not repressed by interferons, and its expression allows for optimal dendritic cell proliferation and T-cell priming in the presence of inflammation
      Title: L-Myc expression by dendritic cells is required for optimal T-cell priming.
    4. We conclude that neither N-Myc nor L-Myc is likely to play important roles in long-term hair cell maintenance
      Title: N-Myc and L-Myc are essential for hair cell formation but not maintenance.
    5. L-Myc, as well as c-Myc mutants (W136E and dN2), all of which have little transformation activity, promoted human iPSC generation more efficiently and specifically compared with WT c-Myc.
      Title: Promotion of direct reprogramming by transformation-deficient Myc.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102165

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of inner ear auditory receptor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein L-Myc
    Names
    L-myc-1 proto-oncogene protein
    lung carcinoma myc related oncogene 1
    protein L-Myc-1
    v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived
    v-myc myelocytomatosis viral oncogene homolog, lung carcinoma derived

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303121.2 → NP_001290050.1  protein L-Myc isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606906
      UniProtKB/Swiss-Prot
      P10166
      Conserved Domains (2) summary
      cd00083
      Location:313 → 367
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam01056
      Location:26 → 249
      Myc_N; Myc amino-terminal region

    2. NM_001421176.1 → NP_001408105.1  protein L-Myc isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL606906

    3. NM_001421177.1 → NP_001408106.1  protein L-Myc isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL606906
      UniProtKB/Swiss-Prot
      P10166, Q5FWI7
      UniProtKB/TrEMBL
      Q3UIE0

    4. NM_008506.4 → NP_032532.1  protein L-Myc isoform 1

      See identical proteins and their annotated locations for NP_032532.1

      Status: VALIDATED

      Source sequence(s)
      AL606906
      Consensus CDS
      CCDS18606.1
      UniProtKB/Swiss-Prot
      P10166, Q5FWI7
      UniProtKB/TrEMBL
      Q3UIE0
      Related
      ENSMUSP00000030407.8, ENSMUST00000030407.8
      Conserved Domains (2) summary
      pfam01056
      Location:2 → 219
      Myc_N; Myc amino-terminal region
      cd11457
      Location:280 → 368
      bHLHzip_L-Myc; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in L-Myc and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      122889414..122896278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10166.1 GenPept UniProtKB/Swiss-Prot:P10166

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