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    Morc2b microrchidia 2B [ Mus musculus (house mouse) ]

    Gene ID: 240069, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Morc2bprovided by MGI
    Official Full Name
    microrchidia 2Bprovided by MGI
    Primary source
    MGI:MGI:3045293
    See related
    Ensembl:ENSMUSG00000048602 AllianceGenome:MGI:3045293
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tce6; 4932411A10Rik
    Summary
    Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and metal ion binding activity. Involved in double-strand break repair involved in meiotic recombination; gamete generation; and homologous chromosome pairing at meiosis. Located in nucleus. Is expressed in germ cell of testis; ovary; spermatid; spermatocyte; and testis. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2Z. Orthologous to human MORC2 (MORC family CW-type zinc finger 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Restricted expression toward testis adult (RPKM 11.0) See more
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    Genomic context

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    See Morc2b in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (33354562..33369473, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33135588..33150499, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42403 Neighboring gene PHD finger protein 8 like Neighboring gene STARR-positive B cell enhancer ABC_E4206 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:33226471-33226658 Neighboring gene zinc finger protein 563 Neighboring gene STARR-seq mESC enhancer starr_42404 Neighboring gene predicted gene, 52288 Neighboring gene predicted gene, 21062 Neighboring gene olfactory receptor family 10 subfamily H member 1B Neighboring gene olfactory receptor family 10 subfamily H member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A histone H3 methyltransferase controls epigenetic events required for meiotic prophase. Hayashi K, et al. Nature, 2005 Nov 17. PMID 16292313
    2. MORC2B is essential for meiotic progression and fertility. Shi B, et al. PLoS Genet, 2018 Jan. PMID 29329290, Free PMC Article
    3. Gene content of the 750-kb critical region for mouse embryonic ectoderm lethal tcl-w5. Abe K, et al. Mamm Genome, 2004 Apr. PMID 15112104
    4. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair involved in meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gamete generation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homologous chromosome pairing at meiosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA methylation-dependent heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATPase MORC2B
    Names
    MORC family CW-type zinc finger protein 2B
    Morc-like protein
    NP_001347132.1
    NP_808387.2
    XP_006524320.1
    XP_006524321.1
    XP_011244746.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360203.1 → NP_001347132.1  ATPase MORC2B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      CT033756
      Consensus CDS
      CCDS37561.1
      UniProtKB/Swiss-Prot
      B8JK02, Q8C5W4, Q8CG24
      UniProtKB/TrEMBL
      Q0VAW0
      Conserved Domains (3) summary
      cd16931
      Location:18 → 135
      HATPase_MORC-like; Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains
      pfam07496
      Location:495 → 540
      zf-CW; CW-type Zinc Finger
      pfam17942
      Location:238 → 451
      Morc6_S5; Morc6 ribosomal protein S5 domain 2-like

    2. NM_177719.4 → NP_808387.2  ATPase MORC2B

      See identical proteins and their annotated locations for NP_808387.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK077016, CT033756
      Consensus CDS
      CCDS37561.1
      UniProtKB/Swiss-Prot
      B8JK02, Q8C5W4, Q8CG24
      UniProtKB/TrEMBL
      Q0VAW0
      Related
      ENSMUSP00000056879.8, ENSMUST00000053896.8
      Conserved Domains (3) summary
      cd16931
      Location:18 → 135
      HATPase_MORC-like; Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains
      pfam07496
      Location:495 → 540
      zf-CW; CW-type Zinc Finger
      pfam17942
      Location:238 → 451
      Morc6_S5; Morc6 ribosomal protein S5 domain 2-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      33354562..33369473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246444.1 → XP_011244746.1  ATPase MORC2B isoform X1

      See identical proteins and their annotated locations for XP_011244746.1

      UniProtKB/Swiss-Prot
      B8JK02, Q8C5W4, Q8CG24
      UniProtKB/TrEMBL
      Q0VAW0
      Conserved Domains (3) summary
      cd16931
      Location:18 → 135
      HATPase_MORC-like; Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains
      pfam07496
      Location:495 → 540
      zf-CW; CW-type Zinc Finger
      pfam17942
      Location:238 → 451
      Morc6_S5; Morc6 ribosomal protein S5 domain 2-like

    2. XM_006524258.4 → XP_006524321.1  ATPase MORC2B isoform X1

      See identical proteins and their annotated locations for XP_006524321.1

      UniProtKB/Swiss-Prot
      B8JK02, Q8C5W4, Q8CG24
      UniProtKB/TrEMBL
      Q0VAW0
      Conserved Domains (3) summary
      cd16931
      Location:18 → 135
      HATPase_MORC-like; Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains
      pfam07496
      Location:495 → 540
      zf-CW; CW-type Zinc Finger
      pfam17942
      Location:238 → 451
      Morc6_S5; Morc6 ribosomal protein S5 domain 2-like

    3. XM_006524257.4 → XP_006524320.1  ATPase MORC2B isoform X1

      See identical proteins and their annotated locations for XP_006524320.1

      UniProtKB/Swiss-Prot
      B8JK02, Q8C5W4, Q8CG24
      UniProtKB/TrEMBL
      Q0VAW0
      Conserved Domains (3) summary
      cd16931
      Location:18 → 135
      HATPase_MORC-like; Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains
      pfam07496
      Location:495 → 540
      zf-CW; CW-type Zinc Finger
      pfam17942
      Location:238 → 451
      Morc6_S5; Morc6 ribosomal protein S5 domain 2-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C5W4.2 GenPept UniProtKB/Swiss-Prot:Q8C5W4

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