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    Tmem178b transmembrane protein 178B [ Mus musculus (house mouse) ]

    Gene ID: 434008, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tmem178bprovided by MGI
    Official Full Name
    transmembrane protein 178Bprovided by MGI
    Primary source
    MGI:MGI:3647581
    See related
    Ensembl:ENSMUSG00000057716 AllianceGenome:MGI:3647581
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm5567; EG434008; A930009E05Rik
    Summary
    Predicted to be active in membrane. Is expressed in cortical plate; dorsal root ganglion; and spinal cord. Orthologous to human TMEM178B (transmembrane protein 178B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 7.1), cortex adult (RPKM 6.9) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem178b in Genome Data Viewer
    Location:
    6 B1; 6 18.82 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (39848164..40232084)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (39871230..40255150)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15673 Neighboring gene predicted gene 7554 Neighboring gene aldolase A, fructose-bisphosphate pseudogene Neighboring gene STARR-seq mESC enhancer starr_15674 Neighboring gene STARR-seq mESC enhancer starr_15675 Neighboring gene STARR-seq mESC enhancer starr_15676 Neighboring gene STARR-seq mESC enhancer starr_15678 Neighboring gene STARR-seq mESC enhancer starr_15681 Neighboring gene STARR-seq mESC enhancer starr_15684 Neighboring gene acylglycerol kinase Neighboring gene DENN domain containing 11 Neighboring gene WEE1 homolog 2 (S. pombe)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Oncogenic BRAF fusions in mucosal melanomas activate the MAPK pathway and are sensitive to MEK/PI3K inhibition or MEK/CDK4/6 inhibition. Kim HS, et al. Oncogene, 2017 Jun 8. PMID 28092667
    2. Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers. Coulpier F, et al. Glia, 2009 Oct. PMID 19243017
    3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 178B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004182.4 → NP_001004182.1  transmembrane protein 178B isoform 2

      See identical proteins and their annotated locations for NP_001004182.1

      Status: VALIDATED

      Source sequence(s)
      AC153728, AK084030, BC051426
      Consensus CDS
      CCDS39465.1
      UniProtKB/TrEMBL
      Q8BNC6
      Related
      ENSMUSP00000055268.7, ENSMUST00000061740.8
      Conserved Domains (1) summary
      cl21598
      Location:2 → 111
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    2. NM_001360978.1 → NP_001347907.1  transmembrane protein 178B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC153377, AC153728, AC155655, BC051426, CD349317
      Consensus CDS
      CCDS90039.1
      UniProtKB/TrEMBL
      A0A5F8MQ13
      Related
      ENSMUSP00000159180.2, ENSMUST00000239008.2
      Conserved Domains (1) summary
      cl21598
      Location:100 → 266
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      39848164..40232084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506361.4 → XP_006506424.1  transmembrane protein 178B isoform X1

      See identical proteins and their annotated locations for XP_006506424.1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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