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    Spred2 sprouty-related EVH1 domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 114716, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Spred2provided by MGI
    Official Full Name
    sprouty-related EVH1 domain containing 2provided by MGI
    Primary source
    MGI:MGI:2150019
    See related
    Ensembl:ENSMUSG00000045671 AllianceGenome:MGI:2150019
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables protein kinase binding activity; protein serine/threonine kinase inhibitor activity; and stem cell factor receptor binding activity. Involved in negative regulation of cell differentiation; regulation of protein modification process; and regulation of signal transduction. Acts upstream of or within negative regulation of MAPK cascade. Located in cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; heart; and sensory organ. Used to study achondroplasia. Human ortholog(s) of this gene implicated in Noonan syndrome. Orthologous to human SPRED2 (sprouty related EVH1 domain containing 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 1.8), adrenal adult (RPKM 1.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Spred2 in Genome Data Viewer
    Location:
    11 A3.1; 11 12.79 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (19874442..19974026)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (19924442..20024026)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39602 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3934 Neighboring gene STARR-seq mESC enhancer starr_28754 Neighboring gene STARR-seq mESC enhancer starr_28757 Neighboring gene STARR-seq mESC enhancer starr_28758 Neighboring gene STARR-seq mESC enhancer starr_28760 Neighboring gene STARR-positive B cell enhancer ABC_E10665 Neighboring gene STARR-seq mESC enhancer starr_28762 Neighboring gene STARR-seq mESC enhancer starr_28763 Neighboring gene STARR-seq mESC enhancer starr_28769 Neighboring gene predicted gene, 39603 Neighboring gene predicted gene, 32080 Neighboring gene actin related protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E1412 Neighboring gene STARR-positive B cell enhancer ABC_E9359

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Spred2 expression during mouse development. Tuduce IL, et al. Dev Dyn, 2010 Nov. PMID 20882678
    2. Identification of SPRED2 (sprouty-related protein with EVH1 domain 2) as a negative regulator of the hypothalamic-pituitary-adrenal axis. Ullrich M, et al. J Biol Chem, 2011 Mar 18. PMID 21199868, Free PMC Article
    3. Spred-2 deficiency exacerbates acetaminophen-induced hepatotoxicity in mice. Wakabayashi H, et al. Clin Immunol, 2012 Sep. PMID 22868447
    4. Spred2-deficiency enhances the proliferation of lung epithelial cells and alleviates pulmonary fibrosis induced by bleomycin. Kawara A, et al. Sci Rep, 2020 Oct 5. PMID 33020583, Free PMC Article
    5. Spred-2 deficiency exacerbates lipopolysaccharide-induced acute lung inflammation in mice. Xu Y, et al. PLoS One, 2014. PMID 25275324, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SPRED2 Is a Novel Regulator of Autophagy in Hepatocellular Carcinoma Cells and Normal Hepatocytes.
      Title: SPRED2 Is a Novel Regulator of Autophagy in Hepatocellular Carcinoma Cells and Normal Hepatocytes.
    2. microRNA-141-3p mediates epithelial cell proliferation, apoptosis, and epithelial-mesenchymal transition and alleviates pulmonary fibrosis in mice via Spred2.
      Title: microRNA-141-3p mediates epithelial cell proliferation, apoptosis, and epithelial-mesenchymal transition and alleviates pulmonary fibrosis in mice via Spred2.
    3. LncRNA TUG1 reverses LPS-induced cell apoptosis and inflammation of macrophage via targeting MiR-221-3p/SPRED2 axis.
      Title: LncRNA TUG1 reverses LPS-induced cell apoptosis and inflammation of macrophage via targeting MiR-221-3p/SPRED2 axis.
    4. Spred2-deficiency enhances the proliferation of lung epithelial cells and alleviates pulmonary fibrosis induced by bleomycin.
      Title: Spred2-deficiency enhances the proliferation of lung epithelial cells and alleviates pulmonary fibrosis induced by bleomycin.
    5. Using established mice lines deficient for either or both Spred 1 and Spred 2, we demonstrate their role in regulating lens development by negatively regulating ERK1/2 activity.
      Title: The negative regulatory Spred1 and Spred2 proteins are required for lens and eye morphogenesis.
    6. SPRED2 deficiency impairs autophagy, leading to cardiac dysfunction and life-threatening arrhythmias.
      Title: SPRED2 deficiency elicits cardiac arrhythmias and premature death via impaired autophagy.
    7. we showed that Spred2-deficiency promotes obesity, adipose tissue inflammation, and insulin resistance, possibly via enhanced adipose tissue inflammation caused by enhanced macrophage activation.
      Title: Spred2 Regulates High Fat Diet-Induced Adipose Tissue Inflammation, and Metabolic Abnormalities in Mice.
    8. Spred2-deficiency protects mice from polymicrobial sepsis via increased activation of the ERK/MAPK pathway and subsequent increase in innate immune responses.
      Title: Spred2-deficiecy Protects Mice from Polymicrobial Septic Peritonitis by Enhancing Inflammation and Bacterial Clearance.
    9. Spred2-/- mice developed severer acute liver injury with increased levels of TNFalpha and IL-1beta in the livers.
      Title: Spred2 Deficiency Exacerbates D-Galactosamine/Lipopolysaccharide -induced Acute Liver Injury in Mice via Increased Production of TNFα.
    10. It is a known inhibitor of ERK1/2 signaling, which influences the severity of lung ischemia reperfusion injury.
      Title: SPRED2 deficiency may lead to lung ischemia-reperfusion injury via ERK1/2 signaling pathway activation.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables stem cell factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of epithelial to mesenchymal transition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of lens fiber cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of protein deacetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sprouty-related, EVH1 domain-containing protein 2
    Names
    sprouty protein with EVH-1 domain 2, related sequence

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033523.4 → NP_277058.1  sprouty-related, EVH1 domain-containing protein 2

      See identical proteins and their annotated locations for NP_277058.1

      Status: PROVISIONAL

      Source sequence(s)
      AL645609, AL672084
      Consensus CDS
      CCDS24454.1
      UniProtKB/Swiss-Prot
      Q924S7
      UniProtKB/TrEMBL
      Q5SRF8
      Related
      ENSMUSP00000090987.6, ENSMUST00000093298.12
      Conserved Domains (2) summary
      cd10574
      Location:12 → 124
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:299 → 397
      Sprouty; Sprouty protein (Spry)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      19874442..19974026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514456.5 → XP_006514519.1  sprouty-related, EVH1 domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      Q5SRF8
      Conserved Domains (2) summary
      cd10574
      Location:29 → 141
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:316 → 414
      Sprouty; Sprouty protein (Spry)

    2. XM_006514458.5 → XP_006514521.1  sprouty-related, EVH1 domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0AAQ4VMS6, Q5SRF8
      Related
      ENSMUSP00000159978.1, ENSMUST00000249881.1
      Conserved Domains (2) summary
      cd10574
      Location:9 → 121
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:296 → 394
      Sprouty; Sprouty protein (Spry)

    3. XM_036156236.1 → XP_036012129.1  sprouty-related, EVH1 domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      Q5SRF8
      Conserved Domains (2) summary
      cd10574
      Location:1 → 104
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:278 → 383
      Sprouty; Sprouty protein (Spry)

    4. XM_006514457.5 → XP_006514520.1  sprouty-related, EVH1 domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      Q5SRF8
      Conserved Domains (2) summary
      cd10574
      Location:12 → 124
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:299 → 397
      Sprouty; Sprouty protein (Spry)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q924S7.1 GenPept UniProtKB/Swiss-Prot:Q924S7

    Gene LinkOut

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