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    Tnfsf13b tumor necrosis factor (ligand) superfamily, member 13b [ Mus musculus (house mouse) ]

    Gene ID: 24099, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Tnfsf13bprovided by MGI
    Official Full Name
    tumor necrosis factor (ligand) superfamily, member 13bprovided by MGI
    Primary source
    MGI:MGI:1344376
    See related
    Ensembl:ENSMUSG00000031497 AllianceGenome:MGI:1344376
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BAFF; BLyS; TALL1; THANK; zTNF4; TALL-1; Tnlg7a; TNFSF20; D8Ertd387e
    Summary
    Predicted to enable receptor ligand activity. Involved in B cell differentiation and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within several processes, including positive regulation of germinal center formation; positive regulation of lymphocyte activation; and transitional one stage B cell differentiation. Predicted to be located in several cellular components, including focal adhesion; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in extracellular space. Is expressed in genitourinary system. Used to study IgA glomerulonephritis and Sjogren's syndrome. Orthologous to human TNFSF13B (TNF superfamily member 13b). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in lung adult (RPKM 5.5), bladder adult (RPKM 3.6) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tnfsf13b in Genome Data Viewer
    Location:
    8 A1.1; 8 4.55 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (10056637..10086000)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (10006229..10036000)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8225 Neighboring gene STARR-positive B cell enhancer ABC_E10489 Neighboring gene abhydrolase domain containing 13 Neighboring gene ligase IV, DNA, ATP-dependent Neighboring gene predicted gene 44788 Neighboring gene STARR-seq mESC enhancer starr_20696 Neighboring gene myosin XVI Neighboring gene predicted gene, 51560

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Normal B cell homeostasis requires B cell activation factor production by radiation-resistant cells. Gorelik L, et al. J Exp Med, 2003 Sep 15. PMID 12975458, Free PMC Article
    2. Mutation of the BAFF furin cleavage site impairs B-cell homeostasis and antibody responses. Bossen C, et al. Eur J Immunol, 2011 Mar. PMID 21287546
    3. Paucity of clinical disease despite serological autoimmunity and kidney pathology in lupus-prone New Zealand mixed 2328 mice deficient in BAFF. Jacob CO, et al. J Immunol, 2006 Aug 15. PMID 16888029, Free PMC Article
    4. BAFF controls B cell metabolic fitness through a PKC beta- and Akt-dependent mechanism. Patke A, et al. J Exp Med, 2006 Oct 30. PMID 17060474, Free PMC Article
    5. Accelerated central nervous system autoimmunity in BAFF-receptor-deficient mice. Kim SS, et al. J Neurol Sci, 2011 Jul 15. PMID 21529843, Free PMC Article

    See all (229) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transcriptome Analysis of BAFF/BAFF-R System in Murine Nephrotoxic Serum Nephritis.
      Title: Transcriptome Analysis of BAFF/BAFF-R System in Murine Nephrotoxic Serum Nephritis.
    2. Blockade of BLyS inhibits B-cell responses and antibody production for the prevention of chronic transplant rejection.
      Title: Blockade of BLyS inhibits B-cell responses and antibody production for the prevention of chronic transplant rejection.
    3. An unappreciated cell survival-independent role for BAFF initiating chronic lymphocytic leukemia.
      Title: An unappreciated cell survival-independent role for BAFF initiating chronic lymphocytic leukemia.
    4. Transcriptome analysis of renal ischemia/reperfusion (I/R) injury in BAFF and BAFF-R deficient mice.
      Title: Transcriptome analysis of renal ischemia/reperfusion (I/R) injury in BAFF and BAFF-R deficient mice.
    5. BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth.
      Title: BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth.
    6. B cell-activating factor (BAFF) from dendritic cells, monocytes and neutrophils is required for B cell maturation and autoantibody production in SLE-like autoimmune disease.
      Title: B cell-activating factor (BAFF) from dendritic cells, monocytes and neutrophils is required for B cell maturation and autoantibody production in SLE-like autoimmune disease.
    7. B Cell and T Cell Dissimilarities in BAFF-Deficient versus BR3-Deficient C57BL/6 Mice.
      Title: B Cell and T Cell Dissimilarities in BAFF-Deficient versus BR3-Deficient C57BL/6 Mice.
    8. BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment.
      Title: BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment.
    9. Possible interplay between estrogen and the BAFF may modify thyroid activity in Graves' disease.
      Title: Possible interplay between estrogen and the BAFF may modify thyroid activity in Graves' disease.
    10. DYRK1a mediates BAFF-induced noncanonical NF-kappaB activation to promote autoimmunity and B-cell leukemogenesis.
      Title: DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis.
    Submit: New GeneRIF Correction See all GeneRIFs (172)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124060, MGC124061

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor ligand activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell costimulation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within B cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of B cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within T cell costimulation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cytokine production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of germinal center formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within immunoglobulin production IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within immunoglobulin production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of B cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of B cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of germinal center formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within skin development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within transitional one stage B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tumor necrosis factor ligand superfamily member 13B
    Names
    b cell-activating factor
    tumor necrosis factor ligand 7a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347309.2 → NP_001334238.1  tumor necrosis factor ligand superfamily member 13B isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC138397
      Consensus CDS
      CCDS85498.1
      UniProtKB/TrEMBL
      Q3U2H2
      Related
      ENSMUSP00000033892.9, ENSMUST00000033892.9

    2. NM_001425009.1 → NP_001411938.1  tumor necrosis factor ligand superfamily member 13B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC138397
      UniProtKB/TrEMBL
      A0A0U5J6R6

    3. NM_033622.3 → NP_296371.1  tumor necrosis factor ligand superfamily member 13B isoform 1

      See identical proteins and their annotated locations for NP_296371.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC138397
      Consensus CDS
      CCDS22094.1
      UniProtKB/Swiss-Prot
      Q7TQ58, Q9WU72
      UniProtKB/TrEMBL
      Q3KP92, Q3U2H2
      Related
      ENSMUSP00000146694.2, ENSMUST00000207792.3
      Conserved Domains (2) summary
      cd00184
      Location:170 → 306
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
      cl11564
      Location:81 → 155
      GcrA; GcrA cell cycle regulator

    RNA

    1. NR_189032.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC138397
      Related
      ENSMUST00000208683.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      10056637..10086000
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WU72.1 GenPept UniProtKB/Swiss-Prot:Q9WU72

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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