Serpina6 serine (or cysteine) peptidase inhibitor, clade A, member 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Serpina6provided by MGI
Official Full Name: serine (or cysteine) peptidase inhibitor, clade A, member 6provided by MGI
Primary source: MGI:MGI:88278
See related: Ensembl:ENSMUSG00000060807 AllianceGenome:MGI:88278
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cbg
Summary: This gene encodes a protein that belongs to the serpin (serine protease inhibitor) family. The encoded protein is an alpha-globulin with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors. [provided by RefSeq, Sep 2015]
Expression: Biased expression in liver E14.5 (RPKM 537.1), liver E14 (RPKM 488.5) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 12 E; 12 52.98 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (103612889..103623477, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (103646630..103657218, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CBG is involved in the gender differences observed in corticosteroids circulating levels and plays a role in the local regulation of corticosteroids availability in organs like lung.
Title: New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver.
the same gene encodes brain and liver corticosteroid-binding globulin
Title: Adrenal steroids in the brain: role of the intrinsic expression of corticosteroid-binding globulin (CBG) in the stress response.
Data suggest fine control interaction between plasma CBG upregulation and stress-induced corticosterone (CORT) release in mouse model of psychological stress; CBG appears to function in maintaining dynamic equilibrium between CBG-bound/-unbound CORT.
Title: Corticosteroid-binding globulin contributes to the neuroendocrine phenotype of mice selected for extremes in stress reactivity.
Sequencing analysis showed that Cbg cDNA obtained from the mouse hypothalamus was homologous to Cbg cDNA obtained from the liver.
Title: Intrinsic expression of transcortin in neural cells of the mouse brain: a histochemical and molecular study.
Cbg-/- mice, unlike controls, remain insensitive to stress applied before memory retrieval. Furthermore, under stress conditions, we observed a blunted surge of corticosterone (CORT) in plasma and no free CORT rise in the hippocampus of Cbg-/-.
Title: Critical role of plasma corticosteroid-binding-globulin during stress to promote glucocorticoid delivery to the brain: impact on memory retrieval.
study describes functional hyporesponsiveness and aldosterone resistance in distal colon of CBG(-/-) mice; steroid actions require an intrinsic but unknown function of CBG, which allows the sufficient supply of the hormone/s to the target tissue
Title: Impaired aldosterone responsiveness in corticosteroid binding globulin deficient mice.
Critical role of plasma Cbg in providing an adequate endocrine and behavioral response to stress.
Title: Plasma transcortin influences endocrine and behavioral stress responses in mice.
These data suggest an active role for CBG in bioavailability, local delivery, and/or cellular signal transduction of glucocorticoids that extends beyond a function as a mere cargo transporter.
Title: Hyporesponsiveness to glucocorticoids in mice genetically deficient for the corticosteroid binding globulin.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (3) 1 citation

General gene information

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Markers

BF388405 (e-PCR)
- UniSTS:244941

RH127840 (e-PCR)
- UniSTS:211150

AV104445 (e-PCR)
- UniSTS:165843

AI265318 (e-PCR)
- UniSTS:160248

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables steroid binding	IDA Inferred from Direct Assay more info	PubMed
enables steroid binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables steroid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within glucocorticoid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: corticosteroid-binding globulin

Names: serine (or cysteine) proteinase inhibitor, clade A, member 6; serpin A6; transcortin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.