Got1 glutamic-oxaloacetic transaminase 1, soluble [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Got1provided by MGI
Official Full Name: glutamic-oxaloacetic transaminase 1, solubleprovided by MGI
Primary source: MGI:MGI:95791
See related: Ensembl:ENSMUSG00000025190 AllianceGenome:MGI:95791
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: cCAT; Got-1; cAspAT
Summary: Enables L-aspartate:2-oxoglutarate aminotransferase activity and phosphatidylserine decarboxylase activity. Involved in gluconeogenesis and malate-aspartate shuttle. Acts upstream of or within several processes, including dicarboxylic acid metabolic process; fatty acid homeostasis; and glycerol biosynthetic process. Is active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in amyloidosis; amyotrophic lateral sclerosis; pancreatic ductal adenocarcinoma; and transient cerebral ischemia. Orthologous to human GOT1 (glutamic-oxaloacetic transaminase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in heart adult (RPKM 196.6), liver adult (RPKM 107.5) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 36.67 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (43488191..43514743, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (43499752..43524605, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glutamate oxaloacetate transaminase 1 is dispensable in macrophage differentiation and anti-pathogen response.
Title: Glutamate oxaloacetate transaminase 1 is dispensable in macrophage differentiation and anti-pathogen response.
High protein diet-induced metabolic changes are transcriptionally regulated via KLF15-dependent and independent pathways.
Title: High protein diet-induced metabolic changes are transcriptionally regulated via KLF15-dependent and independent pathways.
The AhR-hypoxia-inducible factor 1alpha and AhR-GOT1 molecular pathways mediate pulmonary responses on exposure to PM2.5 through their ability to disturb the balance of TH17/Treg cells.
Title: Particulate matter of 2.5 μm or less in diameter disturbs the balance of T(H)17/regulatory T cells by targeting glutamate oxaloacetate transaminase 1 and hypoxia-inducible factor 1α in an asthma model.
cAspAT is a new member of glyceroneogenesis, transcriptionally regulated by TZD via the control of RORalpha expression by PPARgamma in adipocytes
Title: Cytosolic aspartate aminotransferase, a new partner in adipocyte glyceroneogenesis and an atypical target of thiazolidinedione.
aspartate aminotransferase and glutamine synthetase have roles in glucocorticoid activation in mouse Schwann cells
Title: Identification by microarray analysis of aspartate aminotransferase and glutamine synthetase as glucocorticoid target genes in a mouse Schwann cell line.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Got1 (e-PCR), detects polymorphism
- UniSTS:506944

AI789014 (e-PCR)
- UniSTS:160843

GOT1 (e-PCR)
- UniSTS:266597

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-aspartate:2-oxoglutarate aminotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-aspartate:2-oxoglutarate aminotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables L-aspartate:2-oxoglutarate aminotransferase activity	ISO Inferred from Sequence Orthology more info
enables L-aspartate:2-oxoglutarate aminotransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables L-cysteine transaminase activity	ISO Inferred from Sequence Orthology more info
enables L-cysteine transaminase activity	ISS Inferred from Sequence or Structural Similarity more info
enables carboxylic acid binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 2-oxoglutarate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in aspartate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within aspartate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in aspartate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in aspartate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in aspartate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in aspartate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in dicarboxylic acid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in gluconeogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in gluconeogenesis	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within glutamate catabolic process to aspartate	IDA Inferred from Direct Assay more info	PubMed
involved_in glutamate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within glycerol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycerol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in malate-aspartate shuttle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial depolarization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oxaloacetate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in oxaloacetate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in response to glucocorticoid	IEA Inferred from Electronic Annotation more info
involved_in response to transition metal nanoparticle	ISO Inferred from Sequence Orthology more info
involved_in transdifferentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: aspartate aminotransferase, cytoplasmic

Names: cysteine aminotransferase, cytoplasmic; cysteine transaminase, cytoplasmic; cytosolic aspartate aminotransferase; glutamate oxaloacetate transaminase 1, soluble; transaminase A

NP_034454.2

EC 2.6.1.1

EC 2.6.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010324.2 → NP_034454.2 aspartate aminotransferase, cytoplasmic

See identical proteins and their annotated locations for NP_034454.2

Status: VALIDATED

Source sequence(s)

AK146445, AK147807, AV574373, BY441762, CK334037

Consensus CDS

CCDS29832.1

UniProtKB/Swiss-Prot

P05201, Q3UJH8

Related

ENSMUSP00000026196.8, ENSMUST00000026196.14

Conserved Domains (2) summary

pfam00155
Location:31 → 405

Aminotran_1_2; Aminotransferase class I and II

cl18945
Location:1 → 413

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...