S1pr4 sphingosine-1-phosphate receptor 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: S1pr4provided by MGI
Official Full Name: sphingosine-1-phosphate receptor 4provided by MGI
Primary source: MGI:MGI:1333809
See related: Ensembl:ENSMUSG00000044199 AllianceGenome:MGI:1333809
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Edg6; Lpc1; S1p4
Summary: This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for the lysophospholipid sphingosine 1-phosphate. The encoded protein is one of the predominant sphingosine 1-phosphate G-protein coupled receptors expressed in T cells, and it plays a role in suppression of T cell proliferation, generation of cytokines, and potentially other aspects of immune activation. [provided by RefSeq, Feb 2010]
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (81333579..81335971, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (81497745..81500137, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sphingosine-1-Phosphate Receptor 4 links neutrophils and early local inflammation to lymphocyte recruitment into the draining lymph node to facilitate robust germinal center formation.
Title: Sphingosine-1-Phosphate Receptor 4 links neutrophils and early local inflammation to lymphocyte recruitment into the draining lymph node to facilitate robust germinal center formation.
Apolipoprotein M bound sphingosine 1-phosphate suppresses NETosis through activating S1P1 and S1P4.
Title: Apolipoprotein M bound sphingosine 1-phosphate suppresses NETosis through activating S1P1 and S1P4.
Sphingosine-1-Phosphate Receptor 4 Attenuates Neutrophilic Airway Inflammation in Experimental Asthma via Repressing Proinflammatory Macrophage Activation.
Title: Sphingosine-1-Phosphate Receptor 4 Attenuates Neutrophilic Airway Inflammation in Experimental Asthma via Repressing Proinflammatory Macrophage Activation.
Sphingosine 1-Phosphate Receptor 4 Promotes Nonalcoholic Steatohepatitis by Activating NLRP3 Inflammasome.
Title: Sphingosine 1-Phosphate Receptor 4 Promotes Nonalcoholic Steatohepatitis by Activating NLRP3 Inflammasome.
Sphingosine-1-Phosphate Receptor Type 4 (S1P4) Is Differentially Regulated in Peritoneal B1 B Cells upon TLR4 Stimulation and Facilitates the Egress of Peritoneal B1a B Cells and Subsequent Accumulation of Splenic IRA B Cells under Inflammatory Conditions.
Title: Sphingosine-1-Phosphate Receptor Type 4 (S1P(4)) Is Differentially Regulated in Peritoneal B1 B Cells upon TLR4 Stimulation and Facilitates the Egress of Peritoneal B1a B Cells and Subsequent Accumulation of Splenic IRA B Cells under Inflammatory Conditions.
S1PR4 ablation reduces tumor growth and improves chemotherapy via CD8+ T cell expansion.
Title: S1PR4 ablation reduces tumor growth and improves chemotherapy via CD8+ T cell expansion.
S1PR4-dependent CCL2 production promotes macrophage recruitment in a murine psoriasis model.
Title: S1PR4-dependent CCL2 production promotes macrophage recruitment in a murine psoriasis model.
Genetic deletion of S1pr4 resulted in exacerbation of passive systemic anaphylaxis to IgE/anti-IgE.
Title: S1P₄ Regulates Passive Systemic Anaphylaxis in Mice but Is Dispensable for Canonical IgE-Mediated Responses in Mast Cells.
Data shows a reduced abundance of pDC, particularly CD4- pDC, in all organs of S1PR4-deficient vs. wildtype mice.
Title: S1PR4 is required for plasmacytoid dendritic cell differentiation.
analysis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P-R) agonists
Title: Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P₄-R) agonists.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

General gene information

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Markers

UniSTS:495940 (e-PCR)
- UniSTS:495940

Edg6 (e-PCR), detects polymorphism
- UniSTS:495940

Edg6 (e-PCR), detects polymorphism
- UniSTS:474714

Edg6 (e-PCR), detects polymorphism
- UniSTS:496526

NoName (e-PCR)
- UniSTS:484857

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables sphingosine-1-phosphate receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingosine-1-phosphate receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IEP Inferred from Expression Pattern more info	PubMed

General protein information

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Preferred Names: sphingosine 1-phosphate receptor 4

Names: S1P receptor Edg-6; S1p receptor 4; endothelial differentiation G-protein-coupled receptor 6; lysophospholipid receptor C1; sphingosine 1-phosphate receptor Edg-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010102.2 → NP_034232.1 sphingosine 1-phosphate receptor 4

See identical proteins and their annotated locations for NP_034232.1

Status: REVIEWED

Source sequence(s)

AC159474

Consensus CDS

CCDS24059.1

UniProtKB/Swiss-Prot

Q3U4H3, Q8C6E2, Q8K1R9, Q9Z0L1

Related

ENSMUSP00000050412.6, ENSMUST00000053646.7

Conserved Domains (2) summary

cd14964
Location:52 → 76

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:51 → 320

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily