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    Arhgap12 Rho GTPase activating protein 12 [ Mus musculus (house mouse) ]

    Gene ID: 75415, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Arhgap12provided by MGI
    Official Full Name
    Rho GTPase activating protein 12provided by MGI
    Primary source
    MGI:MGI:1922665
    See related
    Ensembl:ENSMUSG00000041225 AllianceGenome:MGI:1922665
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810011M08Rik
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in several processes, including negative regulation of small GTPase mediated signal transduction; phagocytosis, engulfment; and small GTPase-mediated signal transduction. Predicted to be located in phagocytic cup. Predicted to be active in cytoplasm and plasma membrane. Is expressed in bladder; gut; nervous system; sensory organ; and skeleton. Orthologous to human ARHGAP12 (Rho GTPase activating protein 12). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in bladder adult (RPKM 10.7), CNS E14 (RPKM 8.1) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arhgap12 in Genome Data Viewer
    Location:
    18 A1; 18 4.46 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (6024448..6136102, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (6024448..6136098, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34804 Neighboring gene STARR-positive B cell enhancer mm9_chr18:5989955-5990255 Neighboring gene predicted gene, 41663 Neighboring gene predicted gene, 41662 Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase pseudogene Neighboring gene STARR-seq mESC enhancer starr_43701 Neighboring gene predicted gene, 18278 Neighboring gene STARR-positive B cell enhancer ABC_E1514 Neighboring gene STARR-seq mESC enhancer starr_43702 Neighboring gene STARR-seq mESC enhancer starr_43703 Neighboring gene kinesin family member 5B Neighboring gene predicted gene, 41664 Neighboring gene STARR-seq mESC enhancer starr_43704 Neighboring gene STARR-seq mESC enhancer starr_43705 Neighboring gene STARR-seq mESC enhancer starr_43706 Neighboring gene STARR-seq mESC enhancer starr_43709 Neighboring gene STARR-seq mESC enhancer starr_43711 Neighboring gene STARR-seq mESC enhancer starr_43712 Neighboring gene ribosomal protein L27, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Circular RNA Arhgap12 modulates doxorubicin-induced cardiotoxicity by sponging miR-135a-5p. Wang X, et al. Life Sci, 2021 Jan 15. PMID 33245966
    2. Identification of adherens junction-associated GTPase activating proteins by the fluorescence localization-based expression cloning. Matsuda M, et al. Exp Cell Res, 2008 Mar 10. PMID 18241859
    3. Next-generation sequencing of small RNAs from inner ear sensory epithelium identifies microRNAs and defines regulatory pathways. Rudnicki A, et al. BMC Genomics, 2014 Jun 18. PMID 24942165, Free PMC Article
    4. Met-driven invasive growth involves transcriptional regulation of Arhgap12. Gentile A, et al. Oncogene, 2008 Sep 18. PMID 18504429
    5. Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development. Cesari E, et al. Nucleic Acids Res, 2024 May 8. PMID 38324473, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circular RNA Arhgap12 modulates doxorubicin-induced cardiotoxicity by sponging miR-135a-5p.
      Title: Circular RNA Arhgap12 modulates doxorubicin-induced cardiotoxicity by sponging miR-135a-5p.
    2. ARHGAP12 inactivates RAC1, thereby impairing cell motility, invasion and adhesion to the extracellular matrix. The gene is transcriptionally suppressed by Hepatocyte Growth Factor in human and murine cell lines.
      Title: Met-driven invasive growth involves transcriptional regulation of Arhgap12.
    3. Immunofluorescence staining and confocal laser-scanning microscopy demonstrated that Arhgap12 localizes at epithelial cell-cell adherent junctions in various mouse tissues.
      Title: Identification of adherens junction-associated GTPase activating proteins by the fluorescence localization-based expression cloning.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in morphogenesis of an epithelial sheet ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of small GTPase mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of small GTPase mediated signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phagocytosis, engulfment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phagocytosis, engulfment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagocytic cup ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagocytic cup ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 12
    Names
    rho-type GTPase-activating protein 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039692.1 → NP_001034781.1  rho GTPase-activating protein 12 isoform 1

      See identical proteins and their annotated locations for NP_001034781.1

      Status: VALIDATED

      Source sequence(s)
      AC168050, AK031648, AK077063, BC037608
      Consensus CDS
      CCDS37723.1
      UniProtKB/Swiss-Prot
      Q8BVP8, Q8C0D4
      Related
      ENSMUSP00000138585.2, ENSMUST00000182559.8
      Conserved Domains (6) summary
      cd12070
      Location:13 → 72
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd00201
      Location:266 → 296
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd04403
      Location:646 → 831
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:457 → 568
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:467 → 566
      PH; PH domain
      pfam16618
      Location:69 → 264
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    2. NM_029277.2 → NP_083553.2  rho GTPase-activating protein 12 isoform 2

      See identical proteins and their annotated locations for NP_083553.2

      Status: VALIDATED

      Source sequence(s)
      AC168050, AK077063, BC037608
      Consensus CDS
      CCDS37722.1
      UniProtKB/TrEMBL
      B2RUJ8
      Related
      ENSMUSP00000076376.6, ENSMUST00000077128.13
      Conserved Domains (6) summary
      cd12070
      Location:13 → 72
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd00201
      Location:266 → 296
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd04403
      Location:621 → 806
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:432 → 543
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:442 → 541
      PH; PH domain
      pfam16618
      Location:69 → 264
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      6024448..6136102 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250623.2 → XP_030106483.1  rho GTPase-activating protein 12 isoform X8

      Conserved Domains (4) summary
      cd12070
      Location:13 → 72
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd04403
      Location:487 → 672
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:298 → 409
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam16618
      Location:69 → 226
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    2. XM_036161302.1 → XP_036017195.1  rho GTPase-activating protein 12 isoform X7

      Conserved Domains (4) summary
      cd12070
      Location:13 → 72
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd04403
      Location:512 → 697
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:323 → 434
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam16618
      Location:69 → 226
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    3. XM_017318001.2 → XP_017173490.1  rho GTPase-activating protein 12 isoform X6

      Conserved Domains (4) summary
      cd12070
      Location:13 → 72
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd04403
      Location:517 → 702
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:328 → 439
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam16618
      Location:69 → 226
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    4. XM_006526316.2 → XP_006526379.1  rho GTPase-activating protein 12 isoform X5

      UniProtKB/TrEMBL
      S4R203
      Related
      ENSMUSP00000138444.2, ENSMUST00000182383.8
      Conserved Domains (6) summary
      cd12070
      Location:13 → 72
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      COG5104
      Location:257 → 362
      PRP40; Splicing factor [RNA processing and modification]
      cd00201
      Location:266 → 296
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd04403
      Location:574 → 759
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:385 → 496
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam16618
      Location:69 → 264
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    5. XM_036161301.1 → XP_036017194.1  rho GTPase-activating protein 12 isoform X4

      UniProtKB/TrEMBL
      S4R248
      Related
      ENSMUSP00000138496.2, ENSMUST00000182066.8
      Conserved Domains (6) summary
      cd12070
      Location:13 → 72
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      COG5104
      Location:257 → 362
      PRP40; Splicing factor [RNA processing and modification]
      cd00201
      Location:266 → 296
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd04403
      Location:599 → 784
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:410 → 521
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam16618
      Location:69 → 264
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    6. XM_006526315.2 → XP_006526378.1  rho GTPase-activating protein 12 isoform X3

      UniProtKB/TrEMBL
      A0A0A0MQ95
      Related
      ENSMUSP00000054209.8, ENSMUST00000062584.14
      Conserved Domains (6) summary
      cd12070
      Location:13 → 72
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      COG5104
      Location:257 → 362
      PRP40; Splicing factor [RNA processing and modification]
      cd00201
      Location:266 → 296
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd04403
      Location:604 → 789
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:415 → 526
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam16618
      Location:69 → 264
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    7. XM_011247018.2 → XP_011245320.1  rho GTPase-activating protein 12 isoform X2

      Conserved Domains (6) summary
      cd12070
      Location:13 → 72
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      COG5104
      Location:257 → 409
      PRP40; Splicing factor [RNA processing and modification]
      cd00201
      Location:266 → 296
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd04403
      Location:626 → 811
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:437 → 548
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam16618
      Location:69 → 264
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    8. XM_006526314.2 → XP_006526377.1  rho GTPase-activating protein 12 isoform X1

      UniProtKB/TrEMBL
      S4R221
      Related
      ENSMUSP00000138464.2, ENSMUST00000182213.8
      Conserved Domains (6) summary
      cd12070
      Location:13 → 72
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      COG5104
      Location:257 → 409
      PRP40; Splicing factor [RNA processing and modification]
      cd00201
      Location:266 → 296
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd04403
      Location:651 → 836
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:462 → 573
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam16618
      Location:69 → 264
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C0D4.2 GenPept UniProtKB/Swiss-Prot:Q8C0D4

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