Tat tyrosine aminotransferase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tatprovided by MGI
Official Full Name: tyrosine aminotransferaseprovided by MGI
Primary source: MGI:MGI:98487
See related: Ensembl:ENSMUSG00000001670 AllianceGenome:MGI:98487
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: This gene encodes a liver-specific mitochondrial enzyme that catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Regulated by glucocorticoid and polypeptide hormones, this gene's expression is affected by deletion of a regulatory region near the albino locus on chromosome 7. Mutations in this gene cause tyrosinemia type II in humans. [provided by RefSeq, Mar 2010]
Expression: Restricted expression toward liver adult (RPKM 449.0) See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 57.38 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (110712710..110726436)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (109986078..109999804)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tat-heat shock protein 10 ameliorates age-related phenotypes by facilitating neuronal plasticity and reducing age-related genes in the hippocampus.
Title: Tat-heat shock protein 10 ameliorates age-related phenotypes by facilitating neuronal plasticity and reducing age-related genes in the hippocampus.
Tat-CIAPIN1 protein transduced into HT-22cells and significantly inhibited cell death, DNA fragmentation, and reactive oxygen species (ROS) generation.
Title: Tat-CIAPIN1 inhibits hippocampal neuronal cell damage through the MAPK and apoptotic signaling pathways.
Tat-DJ-1 protein protects against dopaminergic neuronal cell death in 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine (MPTP)-induced PD mouse models.
Title: Transduced Tat-DJ-1 protein protects against oxidative stress-induced SH-SY5Y cell death and Parkinson disease in a mouse model.
Through macromolecular crystallography the mTAT crystal structure was revealed at 2.9 A resolution; it showed the interaction between the pyridoxal-5'-phosphate cofactor and the enzyme, as well as the formation of a disulphide bond.
Title: Tyrosine aminotransferase: biochemical and structural properties and molecular dynamics simulations.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

General gene information

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Markers

Tat (e-PCR), detects polymorphism
- UniSTS:144546

Clone Names

MGC37772, MGC37789, MGC37790, MGC37819, MGC37828, MGC37842

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-tyrosine-2-oxoglutarate transaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-tyrosine-2-oxoglutarate transaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables L-tyrosine-2-oxoglutarate transaminase activity	ISO Inferred from Sequence Orthology more info
enables amino acid binding	IEA Inferred from Electronic Annotation more info
enables amino acid binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 2-oxoglutarate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in 2-oxoglutarate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in L-phenylalanine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-phenylalanine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in amino acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glutamate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glutamate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to dexamethasone	IEA Inferred from Electronic Annotation more info
involved_in response to glucocorticoid	ISO Inferred from Sequence Orthology more info
involved_in response to mercury ion	IEA Inferred from Electronic Annotation more info
involved_in response to mercury ion	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in tyrosine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in tyrosine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in tyrosine catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: tyrosine aminotransferase

Names: L-tyrosine:2-oxoglutarate aminotransferase; tyrosine transaminase

NP_666326.1

EC 2.6.1.5

XP_030099366.1

EC 2.6.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_146214.3 → NP_666326.1 tyrosine aminotransferase

See identical proteins and their annotated locations for NP_666326.1

Status: REVIEWED

Source sequence(s)

AC124409

Consensus CDS

CCDS22658.1

UniProtKB/Swiss-Prot

Q3UER7, Q8BTI1, Q8QZR1

UniProtKB/TrEMBL

Q3UEH2

Related

ENSMUSP00000001720.8, ENSMUST00000001720.14

Conserved Domains (2) summary

TIGR01264
Location:41 → 442

tyr_amTase_E; tyrosine aminotransferase, eukaryotic

pfam07706
Location:1 → 40

TAT_ubiq; Aminotransferase ubiquitination site

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

110712710..110726436

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030243506.1 → XP_030099366.1 tyrosine aminotransferase isoform X1

UniProtKB/Swiss-Prot

Q3UER7, Q8BTI1, Q8QZR1

UniProtKB/TrEMBL

Q3UEH2

Conserved Domains (2) summary

TIGR01264
Location:41 → 442

tyr_amTase_E; tyrosine aminotransferase, eukaryotic

pfam07706
Location:1 → 40

TAT_ubiq; Aminotransferase ubiquitination site