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    Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 [ Mus musculus (house mouse) ]

    Gene ID: 216859, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Acap1provided by MGI
    Official Full Name
    ArfGAP with coiled-coil, ankyrin repeat and PH domains 1provided by MGI
    Primary source
    MGI:MGI:2388270
    See related
    Ensembl:ENSMUSG00000001588 AllianceGenome:MGI:2388270
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Centb1
    Summary
    Predicted to enable GTPase activator activity and metal ion binding activity. Predicted to be involved in lipid catabolic process and signal transduction. Predicted to be located in recycling endosome membrane. Is expressed in several structures, including adipose tissue; alimentary system; brain; genitourinary system; and hemolymphoid system. Orthologous to human ACAP1 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in thymus adult (RPKM 113.3), spleen adult (RPKM 55.7) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Acap1 in Genome Data Viewer
    Location:
    11 B3; 11 42.91 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69772393..69786390, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69881566..69895568, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29868 Neighboring gene transmembrane protein 95 Neighboring gene potassium channel tetramerisation domain containing 11 Neighboring gene microRNA 6924 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69708255-69708446 Neighboring gene RIKEN cDNA 2810408A11 gene Neighboring gene STARR-positive B cell enhancer ABC_E7007 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69715057-69715244 Neighboring gene neuralized E3 ubiquitin protein ligase 4 Neighboring gene STARR-positive B cell enhancer ABC_E5243

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ACAP3 regulates neurite outgrowth through its GAP activity specific to Arf6 in mouse hippocampal neurons. Miura Y, et al. Biochem J, 2016 Sep 1. PMID 27330119
    2. Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin. Boles MK, et al. PLoS Genet, 2009 Dec. PMID 20011118, Free PMC Article
    3. Functional genetic analysis of mouse chromosome 11. Kile BT, et al. Nature, 2003 Sep 4. PMID 12955145
    4. Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal. Munger SC, et al. Genes Dev, 2009 Nov 1. PMID 19884258, Free PMC Article
    5. Tie2 regulates endocardial sprouting and myocardial trabeculation. Qu X, et al. JCI Insight, 2019 May 21. PMID 31112136, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

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    Homology

    Clone Names

    • MGC25782, MGC47358

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
    Names
    centaurin, beta 1
    cnt-b1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153788.3 → NP_722483.2  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1

      See identical proteins and their annotated locations for NP_722483.2

      Status: PROVISIONAL

      Source sequence(s)
      AL596185, AL845465
      Consensus CDS
      CCDS24919.1
      UniProtKB/Swiss-Prot
      Q3U441, Q571H6, Q8K2H4
      Related
      ENSMUSP00000001631.7, ENSMUST00000001631.7
      Conserved Domains (5) summary
      cd07639
      Location:18 → 217
      BAR_ACAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 1
      COG0666
      Location:551 → 693
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd13250
      Location:268 → 364
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:575 → 602
      ANK; ANK repeat [structural motif]
      cd08852
      Location:405 → 524
      ArfGap_ACAP1; ArfGAP domain of ACAP1 (ArfGAP with Coiled-coil, ANK repeat and PH domains 1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      69772393..69786390 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314457.3 → XP_017169946.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X1

      Conserved Domains (3) summary
      cd07639
      Location:18 → 217
      BAR_ACAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 1
      cd13250
      Location:268 → 364
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      cl28907
      Location:405 → 524
      ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2H4.1 GenPept UniProtKB/Swiss-Prot:Q8K2H4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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